Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Our previous studies have demonstrated that XIAP promotes bladder cancer metastasis through upregulating RhoGDIβ/MMP-2 pathway. 31240993 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease CTD_human MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer. 30548095 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer. 30548095 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE The identification of the miR-146b/AUF1/ETS2/MMP2 mechanism for promoting bladder cancer invasion provides significant insights into understanding the nature of bladder cancer metastasis. 31071529 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation. 31401412 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion. 31811115 2019
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness. 29588320 2018
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients. 29245935 2017
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE These findings, together with our previous results showing X-link inhibitor of apoptosis protein mediating mRNA stabilization of both RhoGDIβ and mmp-2, reveal the nature of the MMP-2 regulatory network, which leads to MMP-2 overexpression and BC invasion. 28846829 2017
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE Exogenous H2S may promote cell proliferation and invasion by upregulating the expression level of MMP2 and MMP9 in human bladder cancer EJ cells. 29237912 2017
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE RNA interference of HMGB3 in UBC cell lines inhibited cancer cell growth and migration, along with the downregulation of PCNA and MMP2 protein levels. 25647262 2015
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE For the MMP2 -1306 C/T polymorphism, there was a negative association with the T allele for bladder cancer in the Asian population (TT+TC vs. CC: OR = 0.41, 95% CI = 0.18-0.94, pheterogeneity = 0.195). 26301605 2015
Malignant neoplasm of urinary bladder
0.400 Biomarker disease BEFREE Herein, we report the novel concept that miR-20b exerts a suppressive effect on both cell cycle-modulated proliferation and MMP-2-mediated migration and invasion in bladder cancer EJ cells. 26166554 2015
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE Knockdown of GATA3 in the bladder cancer lines (5637, TCC-SUP, J82) resulted in promotion of cell migration and invasion as well as increases in the expression of their related molecules, such as vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9, and the activity of MMP-2 and MMP-9. 24448324 2014
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: a meta-analysis. 24390660 2014
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE The expression of survivin RNA and matrix metalloproteinase 2 and 9 in bladder cancer was compared with benign and normal cases. 22960341 2013
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE The combined genotype MMP2 -1306C/T (rs243865) allele T with MMP9 -1562C/T (rs3918242) allele T was found to increase BC risk (OR 2.00, 95% CI 1.10-3.62; P = 0.022). 23819551 2013
Malignant neoplasm of urinary bladder
0.400 GeneticVariation disease BEFREE Individuals with MMP2 (-1306) TT genotype as well as T allele were at higher risk of BC (P, 0.042; OR, 2.85; P, 0.001; OR, 1.76). 21784671 2013
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE We found that KAI1 expression in bladder cancer cell lines is related to a poor invasive potential and expression of latent MMP-2 but not MMP-9. 20864363 2012
Malignant neoplasm of urinary bladder
0.400 AlteredExpression disease BEFREE MMP-9, MMP-2 and its specific inhibitors expression levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in fresh-frozen malignant tissue collected from 40 patients with BC submitted to transurethral resection of bladder. 22695075 2012