MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 GeneticVariation group GWASCAT Genome-wide association study of colorectal cancer in Hispanics. 27207650 2016
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Therapeutic group RGD Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. 23149858 2013
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group BEFREE Herein we show that MMP-2 is up-regulated in resected colorectal tumors and degrades β1 integrins with the release of fragments containing the β1 I-domain. 22898815 2012
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247 2011
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group BEFREE The high expressions of MMP2 and MMP9 were closely associated with invasion and migration of colorectal tumors and cell lines. 20191032 2010
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer. 18425389 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group CTD_human Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. 18507500 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. 18506186 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 GeneticVariation group LHGDN Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese. 17546628 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group LHGDN Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases. 18214299 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Matrix metalloproteinase (MMP)-7 (matrilysin-1) plays significant roles in the growth, invasion, and metastasis of colorectal tumors, while (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol with chemopreventive properties, has been shown to be an inhibitor of MMP-2 and MMP-9. 15860507 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 GeneticVariation group LHGDN A single nucleotide polymorphism in the matrix metalloproteinase-2 promoter is associated with colorectal cancer. 15485653 2004
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Laminin-5 gamma 2 chain and matrix metalloproteinase-2 may trigger colorectal carcinoma invasiveness through formation of budding tumor cells. 14666611 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group LHGDN Use of plasma MMP-2 and MMP-9 levels as a surrogate for tumour expression in colorectal cancer patients. 14520690 2003
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker group BEFREE Balance between activation and inhibition of matrix metalloproteinase-2 (MMP-2) is altered in colorectal tumors compared to normal colonic epithelium. 12184536 2002
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group BEFREE We evaluated levels and activity of gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as stromelysin-1 (MMP-3) expression in 101 sporadic colorectal tumors in consideration of the microsatellite instability (MSI) status of the groups. 12097300 2002
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 AlteredExpression group BEFREE Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. 8913260 1996