MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE FL-MMP-2 protein levels increased in the cortices and outer medullae of both STZ and db/db mice as a function of the duration of diabetes. 30253743 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE Is cardiovascular disease in patients with diabetes associated with serum levels of MMP-2, LOX, and the elastin degradation products ELM and ELM-2? 28715234 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE Circulating MMP-2 levels are lower and MMP-9 levels are higher in children during DKA compared with levels in children with diabetes without DKA. 26843101 2017
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE We hypothesized that MMP-2 might be a susceptibility gene for cardiovascular disease (CVD) in diabetes. 26025700 2015
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. 24903024 2014
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 GeneticVariation disease BEFREE Although no significant case-control differences in frequency of associated GG(-1575)CC(-1306)TT(-790) MMP-2 promoter genotype were observed, the genotype was found to be significantly less frequent in patients with family history of psoriasis (close as well as distant), family history of diabetes and personal history of allergy (2/11 vs. 55/32, odds ratio (OR) for GGCCTT 0.11, 95% confidential interval 0.02-0.50, Pcorr = 0.01). 19360430 2009
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE Thus, MMP-2 has a proapoptotic role in the loss of retinal capillary cells in diabetes, and the activation of MMP-2 is under the control of superoxide. 19345729 2009
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE Twelve weeks after streptozotocin-induced diabetes, these transgenic mice showed a more severe proteinuria, mesangial expansion, and a decrease in matrix metalloproteinase-2 activity compared to diabetic wild-type mice. 18075496 2008
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE Diabetes upregulated the expression and the gelatinolytic activity of MMP-2 and -9. 16778129 2006
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE The increased MMP-1, MMP-2 and MMP-9 activities induced by high glucose exposure could promote matrix degradation thereby accelerating atherogenesis and potentially reducing plaque stability in diabetes. 12801609 2003
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE These differences may be contributing to the impaired healing of the diabetes mouse; however, they differ from the human data presented here, which show elevated matrix metalloproteinase 2 and reduced matrix metalloproteinase 9 in human diabetic chronic wound fluid compared to acute wound fluid. 12164930 2002
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE We also demonstrate upregulation of the active form of MMP-2 in kidney samples from patients with diabetes. 11457723 2001
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 AlteredExpression disease BEFREE MMP2 gene down-regulation seems to be a molecular epiphenomenon of diabetes, rather than a marker of diabetic nephropathy. 9447953 1997