|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CCL5-directed glioma invasion and increases in MMP-2 were suppressed after inhibition of p-CaMKII.
|
31593589 |
2020 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CCK-8, Transwell migration Assay and Wound-healing assay were appraisal assays for cell proliferation and migration. qRT-PCR and western blot were performed to test the expression of miR-4262, MMP2, MMP13 and LATS1 in glioma cancers tissues and cancer cells.
|
31831299 |
2020 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our research emphasized the suppressive function of miR-93-5p in glioma by targeting MMP2, thus providing some novel experimental basis for the treatment of glioma.
|
31773703 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of MMP-2 and MMP-9 indicates poor prognosis in glioma recurrence.
|
31545229 |
2019 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Analysis by Cox model suggested that tumor diameter, pathological grade and MMP-2 were independent prognostic factors for glioma (P<0.05).
|
30675244 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrated that MMP-2 regulation via EPAC2 overexpression is a novel promising therapeutic route in malignant types of glioma.
|
31186720 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma.
|
30368528 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma.
|
30670934 |
2018 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the presence of activated MMP-2 than that in absence of activated MMP-2 by cells fluorescence test <i>in vitro</i>.
|
29686590 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD34-PAS staining was carried out to observe VM formation, and immunohistochemistry was used to determine the expression levels of Beclin-1, HIF-1α, VEGF and MMP2 in 105 patients with primary glioma.
|
29278874 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Impact of MMP-2 and Its Specific Inhibitor TIMP-2 Expression on the WHO Grade and Prognosis of Gliomas in Chinese Population: a Meta-Analysis.
|
26729052 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that Migfilin is a critical regulator in cellular motility by driving the EGFR-MMP-2 feedback loop, and may be considered as a potential therapeutic target in glioma.
|
29203120 |
2017 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data demonstrate that Diaph1 is highly expressed in human glioma, plays a significant role in glioma cell migration, and can influence the expression and activity of MMP2 and MMP9 indirectly in human glioma cell lines U87 and U251.
|
29035824 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, CCR7 was shown to mediate TGF-β1-induced glioma cancer cell migration by activating matrix metalloproteinase 2 (MMP2)/9.
|
28817313 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similarly, relatively little is known about the relationship of miR-140-5p, vascular endothelial growth factor A, and matrix metalloproteinase-2 in glioma progression.
|
28443475 |
2017 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We examined the potential relationship between MMP2/MMP9 plasma levels and glioma imaging characteristics.
|
28265824 |
2017 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MALAT1-mediated tumor suppression in glioma cells may be via reduction of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling activity and expression of matrix metalloproteinase 2 (MMP2).
|
26938295 |
2016 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Transfection of miR-150-5p or miR-133a mimics into glioma cell lines reduced MT1-MMP expression and MMP-2 activation by these cells, and cell proliferation and invasion/migration were also suppressed by it.
|
27154818 |
2016 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data suggest that SERPINB1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of MMP-2 and the activation of FAK.
|
24968089 |
2015 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 2, critical in human glioma migration and invasion, was down-regulated upon Girdin reduction and led to decreased invasion in vitro and in vivo.
|
25060559 |
2014 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, this compound suppressed the expression of matrix metalloproteinase-2, a key effector of glioma cell invasion, regulated by fibulin-3.
|
23660683 |
2013 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also found HA-induced expression of MMP-2 is blocked by +EGFR signaling, suggesting a connection between CD44 and EGFR in glioma malignancy.
|
23827186 |
2013 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation compared with mock and pSV (scrambled vector) treatments, as determined by 5-bromo-2'-deoxyuridine incorporation, Ki-67 staining and clonogenic survival assay.
|
22349830 |
2013 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our studies on increased anoikis sensitization in matrix metalloproteinase-2 (MMP-2)-knockdown 4910 and 5310 human glioma xenograft cells were interestingly correlated with p21-activated kinase 4 (PAK4) inhibition, prompting us to further investigate the role of PAK4 in glioma.
|
23254288 |
2012 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
By RT-PCR, glioma cell invasion assay showed that the expression of MMP-2 was increased in ppGalNAc-T2-knockdown cells, while the expression of MMP-9 and TGF-β1 was decreased in ppGalNAc-T2-overexpressing cells at the mRNA level.
|
21874244 |
2012 |