|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The present study therefore investigated whether aortic MMP-2 activity is increased by oxidative stress in early hypertension and then contributes to hypertrophic arterial remodeling by reducing the levels of calponin-1.
|
30339939 |
2019 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Vascular MMP-2 expression and activity were assessed by gel zymography, Western blot, and in situ zymography increased with hypertension.
|
30399409 |
2019 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The associations of urinary cadmium with hypertension risk were modified by rs14070 (P-value for interaction = 0.022) and rs7201 (P-value for interaction = 0.009) in gene MMP-2.
|
30684802 |
2019 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MMP-2 activity of thoracic aorta showed no change after hypertension.
|
30336141 |
2018 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Thus, PlGF reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1, MMP-7, and collagen types I and IV induced by placental ischemia and sFlt-1 in HTN in pregnancy.
|
29569955 |
2018 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured).
|
29334797 |
2018 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
The main objective was to analyse whether MMP-2 exerts similar effects on the structure and function of the resistance and conductance arteries during early hypertension.
|
28374979 |
2017 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MMP-2 gene expression demonstrated an AngII-dependent increase in the TA (P < .05), but MMP-9 was not altered with HTN.
|
28034583 |
2017 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
MMP-2 concentrations were 1.02, 1.03 and 1.05 times, and MMP-9 concentrations were 1.03, 1.06 and 1.07 times greater for 1 unit increase in log-transformed water, hair and nail arsenic concentrations, respectively, after adjusting for covariates (age, sex, BMI, smoking habit and hypertension).
|
26637202 |
2015 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In this study, the possible association between MMP-9 and MMP-2 functional promoter polymorphism, stress, and inflammatory markers with development of severe cardiovascular disease (CVD), high blood pressure (HBP), and lupus nephropathy (LN) in SLE patients was investigated.
|
25416694 |
2015 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Increased MMP-2 activity contributes to hypertension-induced maladaptive arterial changes and sustained hypertension.
|
26731549 |
2015 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Furthermore, immunostaining showed that perivascular matrix metalloproteinase-2 was increased in PH patients with RV failure.
|
24705390 |
2014 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI).
|
21307882 |
2012 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Many recent studies have shown the involvement of matrix metalloproteinases (MMPs) in hypertension, particularly MMP-2.
|
18836702 |
2009 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage.
|
17977875 |
2008 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
LHGDN |
The current exploratory work describes that the activity of MMP-2 in the internal mammary artery is correlated with age, hypertension, diabetes and eGFR.
|
18332634 |
2008 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
LHGDN |
Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cells.
|
17188706 |
2007 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results indicate that the Mpv17 protein plays a crucial role in the regulation of MMP-2 and suggest that enhanced MMP-2 expression might mediate the mechanisms leading to glomerulosclerosis, inner ear disease, and hypertension in this model.
|
9658163 |
1998 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
HPO |
|
|
|