MMP2, matrix metallopeptidase 2, 4313

N. diseases: 628; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.330 Biomarker disease CTD_human A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α. 25106431 2014
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.330 AlteredExpression disease BEFREE Fut8 (α1,6-Fucosyltransferase) heterozygous knock-out (Fut8(+/-)) mice had an increased influx of inflammatory cells into the lungs, and this was associated with an up-regulation of matrix metalloproteinases, MMP-2 and MMP-9, after treatment with porcine pancreatic elastase (PPE), exhibiting an emphysema-prone phenotype as compared with wild type mice (Fut8(+/+)). 22732410 2012
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.330 Biomarker disease BEFREE The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1-dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke-related emphysema. 17099140 2007
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema
0.330 Biomarker disease BEFREE The data suggest that the MT1-MMP/MMP-2/TIMP-2 system plays a significant role in the MMP-mediated extracellular matrix degradation and tissue remodeling of emphysematous lungs, and thus may contribute to the weakening of lung parenchyma and lead to the formation of emphysema. 9759652 1998