Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE These LLCm1A cells showed increased production of matrix metalloproteinases (MMPs), including MMP-2, -3, -9, and -13, and pulmonary metastasis following injection into mouse tail veins. 31489536 2020
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE Using a mouse xenograft model, we found that Proscillaridin A treatment significantly inhibited tumor growth and lung metastasis in vivo and decreased the expression levels of Bcl-xl and MMP2. 31708095 2020
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE These results suggest that lidocaine may act, at least partly, via an inhibitory effect on MMP-2 expression to reduce pulmonary metastasis, but whether this is due to an effect on Src or via another pathway remains unclear. 31546727 2019
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE These results suggested that exosomal lnc-MMP2-2 might regulate the migration and invasion of lung cancer cells into the vasculature by promoting MMP2 expression, suggesting this lncRNA as a novel therapeutic target and predictive marker of tumor metastasis in lung cancer. 30256540 2018
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE In conclusion, myricetin could significantly block invasion of MDA-Mb-231Br cells through suppressing the protein expression of MMP-2/9 and the expression of ST6GALNAC5, as well as lung metastasis in a mouse model, which suggests that myricetin should be developed as a potential therapeutic candidate for breast cancer. 29532526 2018
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE In line with in vitro results, in vivo experiments demonstrated that metformin inhibited tumorigenicity, inhibited lung metastasis and down-regulated the expression of MMP-2 and MMP-9. 30481793 2018
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE In addition, caudal vein injecting of Cs-g-PLLD-FA/siAEG-1 complexes inhibited tumor growth and lung metastasis in tumor-bearing mice by silencing AEG-1 and regulating MMP-2/9. 29467575 2018
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9. 30349190 2018
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE The expression level of MMP2 was analyzed in primary OS tissue and lung metastasis tissue using RT-qPCR and IHC methods. 29434926 2018
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Chronic treatment of nude mice, which had been inoculated with MDA-MB-231 cells, with inhibitor 38u via oral administration robustly inhibits breast cancer lung metastasis in a dose-dependent manner, associated with blockade of MMP-2 by AEP. 28820254 2017
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Similarly, eIF4E, VEGF-C, and MMP-2 promoted and E-cadherin suppressed the lung metastasis of CRC cells. 27907907 2016
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE Moreover, lower levels of ERK1/2 phosphorylation and MMP-2 expression were observed in the NPC lung metastases of nude mice administered UCB. 26407680 2016
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE In an orthotopic model of HCC in nude mice, P-5m treatment effectively reduced the lung metastasis as well as the expression of MMP-2 in the tumor tissues. 22395332 2012
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE YSL did not significantly inhibit tumor growth but decreased pulmonary metastasis and prolonged life-span for more than 40 days, which correlated with down-regulation of matrix metalloproteinase-2. 20414698 2011
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE These results reveal that EGCG might decrease MMP-2 mRNA expression through JNK signaling, further suggesting that a combination of EGCG and docetaxel may be a promising strategy to help increase the efficacy of docetaxel in suppressing metastasis in lung cancer cells. 22082235 2011
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. 18777017 2008
Secondary malignant neoplasm of lung
0.100 Biomarker disease BEFREE Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice. 16985063 2006
Secondary malignant neoplasm of lung
0.100 AlteredExpression disease BEFREE Taken together, we have shown that Bcl-2 promotes tumor invasion and lung metastasis by inducing MMP-2 gene expression through the combined action of transcriptional and posttranslational mechanisms. 15994927 2005