Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
These LLCm1A cells showed increased production of matrix metalloproteinases (MMPs), including MMP-2, -3, -9, and -13, and pulmonary metastasis following injection into mouse tail veins.
|
31489536 |
2020 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a mouse xenograft model, we found that Proscillaridin A treatment significantly inhibited tumor growth and lung metastasis in vivo and decreased the expression levels of Bcl-xl and MMP2.
|
31708095 |
2020 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that lidocaine may act, at least partly, via an inhibitory effect on MMP-2 expression to reduce pulmonary metastasis, but whether this is due to an effect on Src or via another pathway remains unclear.
|
31546727 |
2019 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that exosomal lnc-MMP2-2 might regulate the migration and invasion of lung cancer cells into the vasculature by promoting MMP2 expression, suggesting this lncRNA as a novel therapeutic target and predictive marker of tumor metastasis in lung cancer.
|
30256540 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, myricetin could significantly block invasion of MDA-Mb-231Br cells through suppressing the protein expression of MMP-2/9 and the expression of ST6GALNAC5, as well as lung metastasis in a mouse model, which suggests that myricetin should be developed as a potential therapeutic candidate for breast cancer.
|
29532526 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In line with in vitro results, in vivo experiments demonstrated that metformin inhibited tumorigenicity, inhibited lung metastasis and down-regulated the expression of MMP-2 and MMP-9.
|
30481793 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, caudal vein injecting of Cs-g-PLLD-FA/siAEG-1 complexes inhibited tumor growth and lung metastasis in tumor-bearing mice by silencing AEG-1 and regulating MMP-2/9.
|
29467575 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therapeutic effects of tyroserleutide on lung metastasis of human hepatocellular carcinoma SK-HEP-1 and its mechanism affecting ICAM-1 and MMP-2 and -9.
|
30349190 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of MMP2 was analyzed in primary OS tissue and lung metastasis tissue using RT-qPCR and IHC methods.
|
29434926 |
2018 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronic treatment of nude mice, which had been inoculated with MDA-MB-231 cells, with inhibitor 38u via oral administration robustly inhibits breast cancer lung metastasis in a dose-dependent manner, associated with blockade of MMP-2 by AEP.
|
28820254 |
2017 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, eIF4E, VEGF-C, and MMP-2 promoted and E-cadherin suppressed the lung metastasis of CRC cells.
|
27907907 |
2016 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, lower levels of ERK1/2 phosphorylation and MMP-2 expression were observed in the NPC lung metastases of nude mice administered UCB.
|
26407680 |
2016 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In an orthotopic model of HCC in nude mice, P-5m treatment effectively reduced the lung metastasis as well as the expression of MMP-2 in the tumor tissues.
|
22395332 |
2012 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
YSL did not significantly inhibit tumor growth but decreased pulmonary metastasis and prolonged life-span for more than 40 days, which correlated with down-regulation of matrix metalloproteinase-2.
|
20414698 |
2011 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results reveal that EGCG might decrease MMP-2 mRNA expression through JNK signaling, further suggesting that a combination of EGCG and docetaxel may be a promising strategy to help increase the efficacy of docetaxel in suppressing metastasis in lung cancer cells.
|
22082235 |
2011 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis.
|
18777017 |
2008 |
Secondary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice.
|
16985063 |
2006 |
Secondary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, we have shown that Bcl-2 promotes tumor invasion and lung metastasis by inducing MMP-2 gene expression through the combined action of transcriptional and posttranslational mechanisms.
|
15994927 |
2005 |