MMP2, matrix metallopeptidase 2, 4313

N. diseases: 628; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 Biomarker disease BEFREE To analyse predictors of BC, by monitoring in the peripheral blood the biomarkers involved in the inflammation and hepatic fibrosis, such as the matrix metalloproteinases (MMP 2, 9) and their tissue inhibitors (TIMP1), the interleukins (IL 2, 8), alfa-TNF, the endothelins and their receptors. 28922437 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 Biomarker disease CTD_human Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis. 26396155 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 AlteredExpression disease BEFREE In liver fibrosis in both human and mouse tissue MMP expression and activity (MMP-2, -9, -13 and -14) increased with progressive injury and localised to hepatocytes. 25076423 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 Biomarker disease BEFREE Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression. 20563750 2011
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 AlteredExpression disease BEFREE We studied matrix metalloproteinase-2 (MMP-2), -7, -9 and -13 mRNA expressions in the liver tissue of early-stage biliary atresia at the time of Kasai's procedure, late-stage biliary atresia at the time of liver transplantation with advanced fibrosis and nondiseased control without liver fibrosis. 15696117 2005
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 AlteredExpression disease BEFREE Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. 15482348 2005
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 Biomarker disease CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341 2005
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 AlteredExpression disease BEFREE Intrahepatic COX-2, MMP-2, and MMP-9 overexpression is associated with progressive hepatic fibrosis in chronic HCV infection, suggesting their pathogenic role in fibrogenesis. 15479690 2004
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.370 AlteredExpression disease BEFREE Serum MMP-2 and TIMP-1 levels might be useful for estimating the degree of liver fibrosis. 9075665 1997