|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tca83 exhibited an E7 to E6 transcript ratio comparable to HeLa (cervix), targeted the ERK1/2 and MMP2 pathways, and was dependent on E6 and E7 to survive and proliferate.
|
31830929 |
2019 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMP-2 showed the highest value of sensitivity from all examined parameters (in stage I of CC - 93.10%, II - 82.76%, III and IV - 96.88%, total group - 92.05%).
|
30820752 |
2019 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The invasiveness of human cervical cancer associated to the function of Na<sub>V</sub>1.6 channels is mediated by MMP-2 activity.
|
30158710 |
2018 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, this MMP-2 probe potentially provides a sensitive and specific visual method for cervical cancer screening, diagnosis and prognostic judgment.
|
28487974 |
2017 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Following our previous study design, our clinical data showed that NF‑κB and MMP‑2 levels increased in human CaCx specimens with high Cx32 expression compared to levels in para‑carcinoma of cervical specimens.
|
28902345 |
2017 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The leads from the present study suggest the protective role of gene variant -1306C>T at the promoter region of the MMP-2 against HPV-mediated cervical cancer.
|
26561467 |
2016 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that the MMP2 rs243865 and MMP7 rs11568818 genotypes e were associated with increased susceptibility and development of cervical cancer in Chinese Han population.
|
26526578 |
2016 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the chemical inhibition of MMP-2 or MMP-9 significantly reduced the migration of CC Caski or SiHa cells.
|
26191191 |
2015 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expressions were analysed against different age groups, as to demonstrate whether the expression of MMP-2 and MMP-9 is an early or a late event during the progression of cervical cancer.
|
24804816 |
2014 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Membrane type 1-matrix metalloproteinase (MT1-MMP) participates in the activity of MMP-2, which correlates with cancer of uterine cervix.
|
22527983 |
2012 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study shows that MZF-1 represses MMP-2 transcription and suggests that this repression may be linked to inhibition of human cervical cancer cell migration and metastasis.
|
22846578 |
2012 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix.
|
21422052 |
2011 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Twenty cervical cancer and 20 normal tissues from the same patients were collected to detect MMP-2 mRNA expression.
|
18177928 |
2008 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinases (MMPs) MMP-2, MMP-9, and MT1-MMP are required for basement membrane degradation in cervical carcinoma.
|
17167534 |
2006 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MMP-2, SCCA, and TPS protein expression were significantly higher in patients with CC than in normal controls.
|
15665394 |
2004 |
|
Cervix carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These suggest that overexpressions of MMP-2 and MT1-MMP, loss of TIMP-2 expression, and up-regulation of beta-catenin by AAC-11 transfection may contribute to the development of cervical cancer invasion.
|
10780674 |
2000 |
|
Cervix carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both MMP-2 and TIMP-2 have a key role in extracellular matrix invasion in cervical carcinoma, largely through their elaboration by tumor cells.
|
10366463 |
1999 |