MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 AlteredExpression phenotype BEFREE There was no statistically significant correlation between the presence of peritumoral retractions or MMP-2 expression and tumor recurrence and progression. 28752222 2018
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 GeneticVariation phenotype BEFREE Our data suggested that variant allele of MMP2 1306C > T was associated with high risk of tumor recurrence and reduced recurrence free survival in superficial BC patients. 21784671 2013
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 AlteredExpression phenotype BEFREE The elevated enzyme activity of MMP-2 in the non-tumorous tissue resected from stage I NSCLC could be used as a prognostic indicator for post-operative tumor recurrence and the patients' poor survival. 17326127 2007
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 AlteredExpression phenotype BEFREE Ras expression has been suggested as a marker for tumor aggressiveness of breast cancer,including the degrees of invasion and tumor recurrence.We showed previously that H-ras, but not N-ras, up-regulates matrix metalloproteinase 2 expression and induces invasive phenotype in MCF10A human breast epithelial cells (A.Moon, et al.Int.J.Cancer, 85: 176-181, 2000). 14500381 2003
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 AlteredExpression phenotype BEFREE Moreover, tumor recurrence was associated with 4.6- and 2.8-fold (P <.05) higher collagen I and MMP2 mRNA levels, respectively, in hepatocellular carcinomas arising in cirrhotic livers. 11431737 2001
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.060 Biomarker phenotype BEFREE MMP-2 and its ratio to TIMP-2 have been associated with tumor recurrence and progression in a number of human malignancies. 10579795 2000