MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 AlteredExpression disease BEFREE Circulating MMP-2 and IL-18 levels were measured using enzyme linked immunosorbent assay (ELISA) in 94 subjects with acute coronary syndrome (ACS, n=38), stable angina pectoris (SAP, n=27) and healthy individuals (control group, n=29). 29685010 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 Biomarker disease BEFREE In this study, we investigated the expression level of miR-29b and MMP-2 in acute coronary syndrome (ACS) patients, verified whether MMP-2 is the target gene of miR-29b by luciferase reporter gene system, and explored the role of miR-29b in the viability and apoptosis of SMCs. 28988362 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 AlteredExpression disease BEFREE The obtained results permit to conclude that the increased expression of MMP-2 and MMP-9 metalloproteinases and their tissue inhibitor (TIMP-2) is responsible for disturbed equilibrium of the metalloproteinase/tissue inhibitors system and as a consequence, for destabilization of atherosclerotic plaque and occurrence of the acute coronary syndrome in the investigated group of patients. 23793312 2014
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 Biomarker disease BEFREE Increased peripheral blood MMP-2 and MMP-9 in acute coronary syndrome (ACS) may be useful as noninvasive tests for detection of plaque vulnerability. 24938016 2014
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 AlteredExpression disease BEFREE MMP-9, but not TIMP-1 or MMP-2 expression is increased in plaques causing acute coronary syndrome. 17706812 2008
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.050 AlteredExpression disease LHGDN MMP-9, but not TIMP-1 or MMP-2 expression is increased in plaques causing acute coronary syndrome. 17706812 2008