MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948480
Disease: Coronary Restenosis
Coronary Restenosis
0.320 Biomarker disease CTD_human Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. 8662692 1996
CUI: C0948480
Disease: Coronary Restenosis
Coronary Restenosis
0.320 AlteredExpression disease BEFREE This is currently best exemplified by the MMP3 gene 5A/6A polymorphism which has an effect on MMP3 expression and has been shown to be associated with coronary stenosis, myocardial infarction, coronary artery calcification, post-angioplasty coronary restenosis, carotid atherosclerosis, stroke, arterial stiffness, and blood pressure. 16122719 2006
CUI: C0948480
Disease: Coronary Restenosis
Coronary Restenosis
0.320 GeneticVariation disease BEFREE Although we did not test all the known polymorphisms of these genes, using tagging analyses we examined those SNPs covering all known haplotypes of MMP2 and MMP3 to conclude that these genes do not correlate with a genetic risk of coronary restenosis after successful PCI. 21206012 2010