MMP3, matrix metallopeptidase 3, 4314

N. diseases: 473; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Clinical osteoblastic bone metastasis samples had higher levels of Notch3 and MMP-3 compared with patient matched visceral metastases or osteolytic metastasis samples. 31467432 2020
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE What is more, miR-519d expression was inversely correlated with MMP3 expression in OSCC tissues, and high levels of MMP3 expression in OSCC tissues were also associated with the metastasis and poor prognosis of these patients. 31258780 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE CTPS2, TP53I3 and SLC1A1 may serve major roles in osteosarcoma development, and hsa‑miR‑422a, hsa‑miR‑194, MMP3 and VEGFB may be associated with osteosarcoma metastasis. 31173206 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE The CCAAT/enhancer binding protein β (C/EBPβ) and matrix metalloproteinase 3 (MMP3) are thought to play key roles in cancer invasion and metastasis. 30969151 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE In conclusion, overexpression of miR-134 suppresses osteosarcoma cell invasion and metastasis through the inhibition of MMP1 and MMP3 expression. 30977909 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE C/EBPβ Promotion of MMP3-Dependent Tumor Cell Invasion and Association with Metastasis in Colorectal Cancer. 29172775 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE Overall, our data suggest that AA6 determines an α-KG-dependent epigenetic regulation of the TET-miR200-Zeb1/CtBP1-MMP3 axis providing an anti-metastatic effect in a mouse model of breast cancer-associated metastasis. 29988033 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Our results demonstrated that MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma. 27837634 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE Cells that overexpressed SLC39A6 had increased expression of mRNAs and proteins associated with metastasis, such as matrix metalloproteinase (MMP) 1, MMP3, MYC, and snail family transcriptional repressor 2 (SNAI2 or SLUG). 28209530 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE We concluded that overexpression of MMP-3 and uPA, altogether with diminished expression of PAI-1 from metastatic tumors, might be a crucial step towards metastasis in ductal breast cancer. 27975070 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Our results demonstrated that MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma. 27061553 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE NFAT1 Directly Regulates IL8 and MMP3 to Promote Melanoma Tumor Growth and Metastasis. 27013197 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Together, our findings demonstrate that PAFR can activate ERK1/2 pathway, and subsequently increase MMP-3 expression and decrease E-cadherin expression, which finally promote prostate cancer cell growth, invasion and metastasis. 27176648 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE Therefore, we hypothesized that MMP3 governed later stages of disease, including progression to metastasis, and did so through a novel IRF8-MMP3 axis. 26008967 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE However, whether MMP-3 participates in the regulation of metastasis and its mechanisms in glioma is mostly unknown. 25252846 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Our data showed that the expression of PLGF and MMP3 strongly correlated in the larynx carcinoma in the patients, and significant higher levels of PLGF and MMP3 were detected in the larynx carcinoma from the patients with metastasis of the primary cancer. 24946722 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE Data from our study suggest that T3/TR, miR-17, p-AKT and MMP3 activities are interlinked in the regulation of cancer cell metastasis. 23912452 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 GeneticVariation phenotype BEFREE For MMP3 (-1171) 5A/6A, the polymorphism decreased the overall risk of metastasis under two genetic models (recessive: OR = 0.80, 95%CI = 0.64-0.99, dominant: OR = 0.72, 95%CI = 0.56-0.93). 22348060 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE CAV-1 might increase the cell metastasis potential through the interaction with E-cadherin and MMP-3 genes. 19718715 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Our results indicate that Cav-1 and CD147 overexpression predict poor NPC prognosis and enhanced tumor cell migration, which is associated with MMP-3 and MMP-11 (active) secretion. 19582878 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Further, we suggest a role for MT1-MMP in early tumour progression, expression of MMP-1 during metastasis and focal expression pattern of MMP-3 in areas of expansion. 17669621 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 AlteredExpression phenotype BEFREE Increased levels of MMP-3 have been correlated with progression of oncogenesis and metastasis. 18225577 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 Biomarker phenotype BEFREE Matrix metalloproteinase-1 and matrix metalloproteinase-3 are implicated in all steps of cancer initiation, invasion, and metastasis. 16937230 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 GeneticVariation phenotype BEFREE This study examined the association between genotypes and haplotypes in the MMP1-MMP3-MMP12 gene cluster and risk of lung cancer development and metastasis. 17145822 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.300 GeneticVariation phenotype BEFREE The functional promoter polymorphism of MMP3 has been related to the susceptibility in some inflammatory diseases and metastasis of cancers. 16430740 2006