|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
With immunoblotting, qRT-PCR, and/or a fluorescence resonance energy transfer (FRET)-based activity assay, we next measured MMP-3/-9 since they are key effectors of BBB breakdown in stroke.
|
29527151 |
2018 |
|
Cerebrovascular accident
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Accordingly, this study tested the hypothesis that tPA and HG increases MMP3 activity in the brain after stroke through peroxynitrite induced tyrosine nitration.
|
28975464 |
2018 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Male SHRSP, SHRSR, two reciprocal SHRSR/SHRSP-STR1/QTL stroke congenic lines received JD for 4 weeks to detect brain UCP2 gene/protein modulation as compared with regular diet (RD).
|
28640254 |
2017 |
|
Cerebrovascular accident
|
0.300 |
Therapeutic
|
group |
RGD |
Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke.
|
24194350 |
2013 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We investigated the association of single nucleotide polymorphisms (SNPs) of the MMP3 gene with stroke in the Korean population.
|
22175304 |
2012 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
MMP-1 (-1607 G in/del), MMP-3 (-1171 A in/del), and MMP-9 microsatellite ((13-26) CA repeats around -90) PMs have been determined (i) in 204 patients with cerebrovascular disease to assess the association with features of vulnerability in carotid plaques and prevalence of stroke, (ii) in 208 patients with UA/NSTEMI to assess the association with in-hospital clinical outcome.
|
21232745 |
2011 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke.
|
21219546 |
2011 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The MMP3 6A/6A genotype is associated with an increased risk of stroke in hypertensive subjects taking lisinopril compared with patients treated with chlorthalidone, whereas a protective effect was found for 5A/5A individuals treated with lisinopril.
|
21183746 |
2011 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Furthermore, inhibition of LRP suppressed both MMP-3 induction in endothelial cells and the increase in ICB by t-PA treatment after stroke.
|
19608750 |
2009 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
No individual SNP identified MMP3 haplotype 2, and none of the individual MMP3 SNPs were associated with myocardial infarction or stroke.
|
18342317 |
2008 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The likely candidate genes associated with stroke are those that are associated with matrix deposition (stromelysin-1, MMP3), inflammation (IL-6), and lipid metabolism (hepatic lipase, APOE, PON1) and clotting (factor V Leiden, fibrinogen).
|
15767859 |
2005 |