|
Aortic Aneurysm, Abdominal
|
0.300 |
Biomarker
|
disease |
BEFREE |
Deficiency in MMP3 reduces ECM damage and the susceptibility of mice to develop AAA.
|
30479344 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
Biomarker
|
disease |
BEFREE |
Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors.
|
28413030 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
For SNPs that had previously been associated with AAA presence, meta-analysis of currently available data together with the two study cohorts disclosed positive associations for the MMP-3 rs3025058 (OR, 1.15; 95% CI, 1.06-1.25; P = .0009) and MTHFR rs1801133 (OR, 1.07; 95% CI, 1.02-1.12; P = .0088).
|
24613192 |
2015 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A common SNP within the MMP3 promoter region, previously suggested to increase MMP3 expression, appears to be a moderate risk factor for AAA.
|
23813847 |
2014 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found a significant association with an increased risk of AAA for MMP3 (AAA patients n = 1258, controls n = 1406: OR = 1.48 [95% CI = 1.23-1.78], I(2) = 0%) and MMP-13 (AAA patients n = 800, controls n = 843: OR = 1.37 [95% CI = 1.04-1.82], I(2) = 25%) polymorphisms and a trend that did not reach the statistical significance, toward a decreased risk of AAA for MMP2 (AAA patients n = 1090, controls n = 1077: OR = 0.83 [95% CI = .60-1.15], I(2) =7 1%) and ELN (AAA patients n = 904, controls n = 1069: OR = 0.79 [95% CI = .53-1.18], I(2) = 72%) polymorphisms.
|
22094117 |
2012 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to determine whether the presence of the 5A allele in the MMP3 promoter is a risk factor for AAA, and if this allele is associated with an increased expression of MMP3 in the aneurysm wall.
|
17875574 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate the effect of functional polymorphisms in promoters of the MMP-2 (-1306 C > T), MMP-3 (-1171 5A > 6A), MMP-9 (-1562 C > T), MMP-12 (-82 A > G), TIMP-1 (-372 C > T), and PAI-1 (-675 4G > 5G and -847 A > G) genes on the growth rate of small abdominal aortic aneurysms.
|
17182940 |
2006 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that the present real-time RT-PCR method is reliable for the determination of mRNA levels in small samples of vascular tissue and that disproportional expression of both MMP-1 and MMP-3 relative to TIMPs relates pathologically to the evolution of AAA.
|
15530910 |
2004 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
Biomarker
|
disease |
RGD |
Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis.
|
15238617 |
2004 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
AAA wall expressed significantly more stromelysin-1 (MMP-3) (mean log(10) ratio [copy enzyme cDNA/copy GAPDH cDNA], -1.9; range, -3.3 to -0.7) than the AOD wall (mean, 4; range, -5.7 to -2.4), P<0.005.
|
11815431 |
2002 |
|
Aortic Aneurysm, Abdominal
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
They are in agreement with previous studies demonstrating higher level of MMP3 expression in AAA than in control tissues.
|
10558909 |
1999 |