Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Of 16 MMPs evaluated, only MMP-9 was significantly (P <.005) upregulated in both AAA and AOD.
|
11854734 |
2002 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
As to mechanism, we found that RAGE was coexpressed in AAA macrophages with MMP-9, a promoter of matrix degradation, which is known to induce AAA.
|
19652591 |
2009 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Although recruitment closed early because of increasing statin use among eligible patients, with only 21 patients we demonstrated a 40% reduction in MMP-9 levels in the AAA wall in patients randomised to simvastatin.
|
17574455 |
2007 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, blood concentrations of MMP-9 and IL-6 measured in middle age predicted the risk of AAA during 24 years of follow-up.
|
29945457 |
2019 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Quantitative competitive reverse transcription-polymerase chain reaction and gelatin zymography showed increased MMP-9 mRNA and protein in both AAA and AOD tissues compared with those in control tissue, but there was no significant difference between AAA and AOD.
|
9763536 |
1998 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm.
|
29687775 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RELMβ gene deficiency significantly decreased AAA incidence and severity, which was associated with reduced macrophage accumulation and decreased expression of proinflammatory cytokines (monocyte chemoattractant protein 1 and interleukin 6), matrix metalloproteinase 2 (MMP-2) and MMP-9 in the aortic wall.
|
29262630 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this rare case of abdominal aortic aneurysm associated with multiple peripheral aneurysms, both plasma and tissue levels of MMP-9 and NGAL seemed to correlate with disease progression.
|
23988549 |
2013 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preoperative treatment with doxycycline was associated with a 3-fold reduction in aortic wall expression of MMP-2 and a 4-fold reduction in MMP-9 (p < 0.05 compared to untreated AAA).
|
10415728 |
1999 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Gambogic acid treatment markedly decreased the levels of proinflammatory cytokines and oxidative stress factors, and transforming growth factor‑β (TGF‑β) and matrix metalloproteinase (MMP)‑2 and MMP‑9 protein expression in AAA mice.
|
30535428 |
2019 |
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We further demonstrated an association between osteogenesis and inflammation; indeed, ha-MSCs cultured with either cytokines (TNF-α, IL-1β) or AAA-PBMCs showed increased expression of MMP-9 and osteogenic markers, to the detriment of the adipogenic regulator PPAR-γ.
|
28446225 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Transfection of the Egr-1 specific synthetic DNA enzyme EDRz significantly reduced AAA following elastase infusion in rats, at least in part due to the decreased expression of downstream MMP-2 and MMP-9.
|
29977360 |
2018 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Endothelial MMP-9 drives the inflammatory response in abdominal aortic aneurysm (AAA).
|
29312500 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the hypothesis that thin ILT is correlated with an increase in oxidative stress-related enzymes and matrix metalloproteinase-9 (MMP-9) expression within the human AAA wall was investigated.
|
30351992 |
2019 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicated that nifedipine inhibits the progression of experimental AAA possibly through suppression of NF-kappaB and MMP-9 activity, leading to protective effects against AAA beyond those associated with blood pressure lowering.
|
18204791 |
2008 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
MMP-9 in AAA group at T14 (p<0.05 compared with T7 and p<0.005 compared with T0) and calprotectin in AAA group at T14 (p<0.001 compared with T7 and T0) continued to significantly increase at all times.
|
28155626 |
2018 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The findings promoted us to test whether aneurysmal prone factors could up-regulate the expression of MMP-2 and MMP-9 through aberrantly increased HIF-1α and promote AAA development.
|
27363580 |
2016 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that MURC/Cavin-4 in VSMCs modulates AAA progression at the early stage via the activation of JNK and MMP-9.
|
28433630 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA.
|
12208863 |
2002 |
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Densitometric analysis confirmed differences in expression for 20 of these gene products between AAAs and normal aorta, with the greatest increases seen for myeloid cell nuclear differentiation antigen (31-fold), cathepsin H (30-fold), platelet-derived growth factor-A (23-fold), apolipoprotein E (13-fold), gelatinase B/matrix metalloproteinase-9 (12-fold), and interleukin-8 (11-fold).
|
11436088 |
2001 |
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While the patient with Behcet's had low protein level, another patient with AAA had high of MMP-9 level.
|
20842516 |
2011 |
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The combined approach of direct experimental confirmation of the functional alterations of MMP-9 SNPs and logistic-regression analysis revealed significant association between MMP-9 genotype and abdominal aortic aneurysm.
|
22942228 |
2012 |
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors.
|
28413030 |
2017 |
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The adjusted recessive models also showed increased risk for AAA for the carriers of MMP-9 T allele (OR = 15.69, 95% CI = 1.40-175.41, p = 0.025).
|
27533781 |
2016 |