|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, blood concentrations of MMP-9 and IL-6 measured in middle age predicted the risk of AAA during 24 years of follow-up.
|
29945457 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, NGAL in complex with activated MMP-9 is present in AAA wall and thrombus.
|
17721627 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast to plasma MMP-9, soluble glycoprotein V (sGPV) and plasmin-antiplasmin complex levels, plasma TIMP-3 levels were not correlated to AAA size but interestingly correlated to sGPV, a platelet activation marker.
|
20513153 |
2010 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
In in vivo experiments, 800 mg/kg GSP could significantly reduce the incidence of AAA, the dilatation of aorta and elastin degradation in media, and dramatically decrease macrophage infiltration and activation and expression of matrix metalloproteinase (MMP) -2 and MMP-9 in the aorta, compared to the AAA model group.
|
28839206 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the hypothesis that thin ILT is correlated with an increase in oxidative stress-related enzymes and matrix metalloproteinase-9 (MMP-9) expression within the human AAA wall was investigated.
|
30351992 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this rare case of abdominal aortic aneurysm associated with multiple peripheral aneurysms, both plasma and tissue levels of MMP-9 and NGAL seemed to correlate with disease progression.
|
23988549 |
2013 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vitro study showed that treating VSMCs with TNF-α together with DOX remarkably inhibited the expressions and activities of MMPs (MMP-2 and MMP-9), significantly suppressed the activation of protein kinase B (AKT) signaling pathway and mitogen-activated protein kinases (MAPKs) signal proteins, including extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK) and p38, and downregulated mRNA levels of interleukin-6 (IL-6) and monocyte chemotactic protein 1 (MCP-1), and significantly upregulated mRNA levels of transforming growth factor beta (TGF-β), heme oxygenase 1 (HO-1) and superoxide dismutase 1 (SOD-1), indicating that DOX inhibits activities of MMPs through reducing oxidative stress, suppressing MAPKs and AKT signaling pathways and ameliorating inflammation in VSMCs, and therefore, exerts preventive as well as therapeutic effects on AAA.
|
28545777 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It is noteworthy that contrary to a previous study, we did not find an association between the MMP9 (nt-1562) polymorphism and AAA, suggesting genetic heterogeneity of the disease.
|
15944607 |
2005 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Low molecular weight heparin treatment decreases MMP-9 plasma activity in patients with abdominal aortic aneurysm.
|
17964826 |
2008 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MMP3, MMP9, and PAI-1 are present at increased levels in abdominal aortic aneurysms (AAAs).
|
10558909 |
1999 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis.
|
30373522 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MSCs with stemness properties are niched in human AAA tissues and display a dysregulation of functional activities; that is, upregulation of MMP-9 and ineffective immunomodulatory capacity, which are crucial in the AAA progression; the possibility to modulate the increased MMP-9 expression by healthy MSCs and IL-10 suggests that novel therapeutic strategies are possible for slowing down AAA progression.
|
25854712 |
2015 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations with AAA were identified for other SNPs assessed in this study including rs1799750 (MMP1), rs3918242 (MMP9), rs486055 (MMP10), rs2276109 (MMP12), rs2252070 (MMP13), rs4898 (TIMP1) or rs9619311 (TIMP3).
|
23813847 |
2014 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Of 16 MMPs evaluated, only MMP-9 was significantly (P <.005) upregulated in both AAA and AOD.
|
11854734 |
2002 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our previous studies have demonstrated that macrophages are the major source of matrix metalloproteinase-9, which is required for aneurysmal degeneration in the murine AAA model.
|
14764734 |
2004 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that MURC/Cavin-4 in VSMCs modulates AAA progression at the early stage via the activation of JNK and MMP-9.
|
28433630 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Plasma protein levels were significantly elevated for osteopontin, MMP-2, and MMP-9 in the samples of ascending and abdominal aortic aneurysm group compared with controls.
|
22571802 |
2013 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm.
|
18763261 |
2008 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preoperative treatment with doxycycline was associated with a 3-fold reduction in aortic wall expression of MMP-2 and a 4-fold reduction in MMP-9 (p < 0.05 compared to untreated AAA).
|
10415728 |
1999 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Quantitative competitive reverse transcription-polymerase chain reaction and gelatin zymography showed increased MMP-9 mRNA and protein in both AAA and AOD tissues compared with those in control tissue, but there was no significant difference between AAA and AOD.
|
9763536 |
1998 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RELMβ gene deficiency significantly decreased AAA incidence and severity, which was associated with reduced macrophage accumulation and decreased expression of proinflammatory cytokines (monocyte chemoattractant protein 1 and interleukin 6), matrix metalloproteinase 2 (MMP-2) and MMP-9 in the aortic wall.
|
29262630 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors.
|
28413030 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sunitinib therapy substantially mitigated both AAA formation and further progression of established AAAs, attenuated aneurysmal aortic MMP2 (matrix metalloproteinase) and MMP9 protein expression, inhibited inflammatory monocyte and neutrophil chemotaxis to VEGF-A, and reduced MMP2, MMP9, and VEGF-A mRNA expression in macrophages and smooth muscle cells in vitro.
|
31294623 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicated that nifedipine inhibits the progression of experimental AAA possibly through suppression of NF-kappaB and MMP-9 activity, leading to protective effects against AAA beyond those associated with blood pressure lowering.
|
18204791 |
2008 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The adjusted recessive models also showed increased risk for AAA for the carriers of MMP-9 T allele (OR = 15.69, 95% CI = 1.40-175.41, p = 0.025).
|
27533781 |
2016 |