Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of Matrix Metalloproteinase 9 (<i>MMP-9</i>) Polymorphisms with Asthma Risk: A Meta-Analysis.
|
30931075 |
2019 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MMP-1 and MMP-9 expression was increased in the nasal tissues of smokers with asthma and CRS via real-time PCR and western blot.
|
31653934 |
2019 |
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
AMs of asthma with a fast FEV<sub>1</sub> decline released a higher level of MMP-9 (8.52 ± 3.53 pg/mL, <i>p</i> < 0.05) than those of a slow FEV<sub>1</sub> decline (0.99 ± 0.20 pg/mL).
|
31547356 |
2019 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, mediators or cytokines, including cysteinyl leukotrienes, matrix metallopeptidase-9, interleukin-33 and eosinophil expression of transforming growth factor-β, may contribute to airway remodeling in asthma.
|
31332973 |
2019 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The increase of oxidative stress and subsequent enhancement of MMP9 and TGF-<i>β</i>1 expression were rescued by the administration of Tetrandrine in the rat model of asthma.
|
31781316 |
2019 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Rutin also inhibited the expression of matrix metalloproteinase 9, thereby aiding in prevention of airway remodelling in asthma thereby revealing to be a potent candidate in asthma therapy.
|
30181695 |
2018 |
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether variants in 3' end of the MMP9 gene are associated with clinical phenotype and responsiveness to treatment in children with asthma.
|
29600353 |
2018 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of ORMDL3, phosphorylated (p)‑ERK and MMP‑9 were significantly greater in the asthma‑model group; however, in the group pretreated with budesonide their expression was reduced.
|
28358425 |
2017 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There was no association between IL-6 and MMP-9 with asthma duration, total IgE, AEC, number of allergens sensitized and degree of sensitization.
|
27780376 |
2017 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have found that MMP-9 concentration in breath condensates of children with stable asthma was slightly higher in ELISA, than in the activity assay.
|
27395373 |
2017 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study indicates that CTGF upregulation correlates with MMP-9, probably involved in the pathogenesis of airway remodeling of asthma.
|
28507585 |
2017 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.
|
26123447 |
2016 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Despite chronic treatment with inhaled steroids mean MMP-9/EBC activity in asthma group was significantly higher than in healthy controls.
|
25650123 |
2015 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate whether MMP-9 SNPs are associated with childhood-onset asthma in Mexican patients we conducted a case-control study including 403 children with clinical asthma diagnoses and 426 healthy controls from Mexico.
|
23639553 |
2013 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model.
|
23244755 |
2012 |
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the mean serum levels of MMP-9 in the children with asthma (136.53 ± 29.96 ng/ml) were significantly higher than that in the healthy controls (45.08 ± 12.53 ng/ml; P<0.05).
|
22052126 |
2012 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the role of the AP-1 sites within the MMP-9 promoter and the effect of commonly used asthma pharmacotherapies in modulating human rhinovirus (HRV)-induced MMP-9 production have not yet been elucidated.
|
22461694 |
2012 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 9 (MMP9) gene has been shown to be involved in the pathogenesis of allergic rhinitis (AR) and asthma.
|
22237587 |
2012 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
MMP-9 (gelatinase B) is recognized in chronic obstructive pulmonary disease (COPD) and now asthma as playing a central role in matrix degradation in injury, as well as contributing to the remodeling process.
|
21644819 |
2012 |
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genotyping of four HapMap derived tagging SNPs in the MMP-9 gene was performed using MALDI-TOF MS in three cross sectional study populations of German children (age 9-11; N = 4,264) phenotyped for asthma and atopic diseases according to ISAAC standard procedures.
|
20181264 |
2010 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Functionally, MMP-9-deficient mice had more acute allergic inflammation than wild-type mice, suggesting that MMP-9 was protective against experimentally induced asthma.
|
19667087 |
2009 |
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A disintegrin and metalloproteinase 33 (ADAM33) and matrix metalloproteinase-9 (MMP9) appear to have important roles in asthma and COPD pathogenesis.
|
17403951 |
2007 |
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms.
|
16631427 |
2006 |
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Thus, the MMP-9 gene might be involved in the development of asthma through functional genetic polymorphisms.
|
16631427 |
2006 |
Asthma
|
0.600 |
Biomarker
|
disease |
LHGDN |
Levels of MMP-9 and TIMP-1 in BAL cell of asthmatic children were increased significantly at about 30- and 35-fold relative to the controls, respectively.
|
16754484 |
2006 |