|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes, such as cancer metastasis.
|
31820313 |
2020 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Mechanistically, we found that the phosphatidylinositol 3-kinase-AKT signal pathway and its downstream effectors, such as tissue inhibitor of metalloproteinases 1 and matrix metallopeptidase 9, were required for MUC13-mediated tumor metastasis of iCCA.
|
31837357 |
2020 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Importantly, this biosensor reports back on molecular signatures characteristic to metastatic tumors and associated with poor prognosis - MMP9 protease overexpression.
|
31747099 |
2020 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Migration and invasion potential of SGC7901 cells, EMT biomarkers and MMP-9 in SGC7901 cells, and metastasis of gastric cancer to lungs in mice were coordinately inhibited by DAPT and LY294002.
|
31732769 |
2020 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The elevated sequential activation of AR/PIP5K1α/AKT/MMP9/VEGF signaling axis contributed to increased invasiveness and growth of metastatic tumors.
|
31381135 |
2020 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of miR-574-5p induced an up-regulation of E-cadherin and down-regulation of cyclinD1, N-cadherin, matrix metallopeptidase 9 (MMP-9), and β-catenin in cervical cancer cells Moreover, QKI was verified as a target of miR-574-5p and involved in regulation of miR-574-5p-induced cervical cancer cell progression and metastasis. miR-574-5p functions to be oncogenic in cervical cancer, and its inhibition suppresses cervical cancer progression and metastasis as well as enhances chemosensitivity by targeting QKI.
|
31786621 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Impact Statement Cancer invasion and metastasis have been shown to be driven by matrix metalloproteinase 9 (MMP9), whose expression mechanism is not clarified yet.
|
30734664 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
MPPa-PDT downregulated the expression of MMP2 and MMP9, which are responsible for the initiation of metastasis.
|
31783821 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
This signal circuit was essential for regulating the expression of epithelial mesenchymal transition (EMT) factors, such as Snail, Zeb1, E-cadherin, and matrix metalloproteinase 9, involved in HCC cell migration and metastasis.
|
31387985 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Our results showed, reduction in MMP-2 (p=0.08), MMP-9 (p=0.03), CCL22 (p=0.003) and TGFβ1 (p=0.1) gene expression and Tregs frequency (p=0.01) which play a main role in the development of chronic inflammation, angiogenesis, tumorigenesis and metastasis.
|
30848576 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the down-regulation of matrix metalloprotein 2 (MMP2) and MMP9 also reduce the rate of tumor metastasis.
|
31136911 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase 9 (MMP9) is involved in the proteolysis of extracellular proteins and plays a critical role in pancreatic ductal adenocarcinoma (PDAC) progression, invasion and metastasis.
|
30941918 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-9 (MMP-9) is a significant target for the development of drugs for the treatment of arthritis, CNS disorders, and cancer metastasis.
|
29475408 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Matrix metalloproteinase-9 (MMP-9) is responsible for matrix degradation, cancer invasion and metastasis.
|
31831717 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Lycorine inhibits melanoma cell migration and metastasis mainly through reducing intracellular levels of β-catenin and matrix metallopeptidase 9.
|
30565685 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, the protein and mRNA expression levels of metastasis-related genes, including N-cadherin, Vimentin, MMP2 and MMP9, were markedly decreased in the DKK3 and miR-125a inhibitor groups compared to their control groups and markedly increased in the DKK3 shRNA and miR-125a groups compared with the control group.
|
31423109 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, we demonstrated that N-glycosylation mutation of EpCAM-mediated invasion and metastasis of breast carcinoma cells required the downregulation of MMP-9 via inhibition of these two signaling pathways.
|
30246502 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The injection of si-ERβ-transfected U2-OS cells into mice significantly increased the subcutaneous tumor volume; the expression of β-catenin, MMP-7, and MMP-9; and the number of metastatic tumors in liver tissues.
|
31692529 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, our findings suggest that MIF may promote the invasion and metastasis of OSCC through the activation of MMP-2 and MMP-9 and prompt further investigation into the therapeutic value of MIF for OSCC treatment.
|
31219646 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The cytokine-mediated upregulation of metastasis- and inflammatory-associated genes, which are downstream genes of STAT3 including the intercellular adhesion molecule-1, matrix metalloproteinase-9, inducible nitric oxide synthase, and cyclo-oxygenase 2 (COX-2), were also significantly abolished by myricetin treatment.
|
30880773 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Melanoma metastasis requires migration and invasion of the malignant tumour cells driven by proteolytic remodelling of the extracellular matrix (ECM) executed by matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9.
|
31020875 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Using this method to select from synthetic human antibody libraries, we isolated panels of mAbs inhibiting 5 targets of 4 main protease classes: matrix metalloproteinases (MMP-14, a predominant target in metastasis; MMP-9, in neuropathic pain), β-secretase 1 (BACE-1, an aspartic protease in Alzheimer's disease), cathepsin B (a cysteine protease in cancer), and Alp2 (a serine protease in aspergillosis).
|
31363054 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of MMP-9 is associated with the spinal metastasis of gastric carcinoma.
|
30570882 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These results indicated that sevoflurane suppressed cell migration and invasion through regulating ERK/MMP-9 pathway via miR-203/Robo1 in CRC cells, indicating important clinical implications for anesthetic agents to prevent metastasis in CRC.
|
30685432 |
2019 |
|
Neoplasm Metastasis
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC.
|
31281549 |
2019 |