Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a population cohort, we found that individuals homozygous for the MMP12 low expression allele had higher plasma fibrinogen levels (2.95 mg/mL compared with 2.61 mg/mL in other individuals, p=0.029) and increased risk of advanced atherosclerosis [odds ratio 6.3 (95% CI 1.9-20.8), p=0.003] and myocardial infarction [hazard ratio 5.6 (95% CI 1.7-18.3), p=0.005].
|
22119538 |
2012 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Through screening expression patterns of typical genes involved in atherosclerosis and foam cell generation, we could demonstrate that mRNA levels of cyclooxygenase-2, interleukin 1beta, and tumor necrosis factor-alpha were increased in a time- and dose-dependent manner in U937 macrophages treated with TCDD, like oxLDL, and that these changes accompanied significantly elevated levels of matrix-degrading metalloproteinases (MMP)-1, MMP-3, MMP-12, and MMP-13.
|
15531779 |
2004 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The main pathologic role of MMP-12 overexpression was suggested to be associated with pathogenesis mechanism of inflammatory respiratory diseases and atherosclerosis.
|
29423648 |
2018 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human metalloelastase (MMP-12) is an MMP, the expression of which has so far been documented in macrophages associated with atherosclerosis, wound repair, and certain cancers.
|
11704502 |
2001 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events.
|
29434795 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMP-12 is a key enzyme in diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis.
|
29660282 |
2018 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data support cholesterol-independent causal relationships between estrogen, oxidized LDL-induced secretion of macrophage MMP12, and arterial stiffness that protect against atherosclerosis in females and emphasize that reduced MMP12 functionality can confer atheroprotection to males.
|
30626744 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, a specific MMP-12 inhibitor might prove useful for the treatment of progressive atherosclerosis.
|
18403602 |
2008 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of matrix metalloproteinase 12 (MMP-12) has been found in atherosclerosis, stiffed vascular tissue, and calcified aortic valves.
|
30691826 |
2019 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we evaluated and extended these results by examining the relationship between MMP12 and atherosclerosis in clinical and experimental studies.
|
28734077 |
2017 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, MMP-12 is induced by several factors implicated in atherosclerosis.
|
10825169 |
2000 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Therefore, a specific MMP-12 inhibitor might prove useful for the treatment of progressive atherosclerosis.
|
18403602 |
2008 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased matrix metalloproteinase-12 (MMP-12) has been implicated in atherosclerosis and many other inflammatory processes.
|
15359603 |
2004 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of ApoE-/- mice to TCDD caused a time-dependent progression of atherosclerosis, which was associated with induction of inflammatory genes, including interleukin-8, as well as F4/80 and matrix metalloproteinase-12.
|
21441140 |
2011 |