Adenocarcinoma of lung (disorder)
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we report preliminary results indicating that the T24 bladder carcinoma oncogene is highly related to the transforming gene of BALB-MSV, an acute transforming retrovirus.
|
6761348 |
1982 |
Myeloid Leukemia, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
A remarkable concordance between the chromosomal location of human cellular oncogenes and the breakpoints involved in acquired chromosomal translocations is becoming apparent in various cancers: the oncogenes c-mos, c-myc and c-abl are located at the breakpoints that occur in acute myeloblastic leukaemia, Burkitt's lymphoma and chronic myelocytic leukaemia respectively.
|
6312328 |
1983 |
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
We have, therefore, analyzed the level of transcription of the cellular myc and mos genes in a variety of undifferentiated B cell lymphomas of Burkitt and non-Burkitt type that possess either an 8;14 or an 8;22 translocation.
|
6300881 |
1983 |
Neoplasms
|
0.090 |
GeneticVariation
|
group |
BEFREE |
Thus, trisomy 8 associated with human hematologic neoplasia is generally not related to gross rearrangements of the c-mos or c-myc genes.
|
4079453 |
1985 |
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
To determine whether the c-mos oncogene has been translocated in AML-M2 with this translocation and to isolate DNA sequences and genes from these two chromosomes that may be important in malignancy, we constructed somatic cell hybrids between a Chinese hamster ovary cell (CHO) mutant defective in glycine metabolism and myeloblasts with an 8;21 translocation from a patient with AML.
|
2982159 |
1985 |
Leukemia, Myelocytic, Acute
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We isolated the 21q+ chromosome of this translocation in a somatic cell hybrid and showed that the c-mos oncogene had not been translocated to chromosome 21, ruling out the possibility that translocation of c-mos to chromosome 21 is necessary for development of AML-M2.
|
2982159 |
1985 |
Leukemia, Myelocytic, Acute
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia.
|
3860954 |
1985 |
Primary malignant neoplasm
|
0.050 |
GeneticVariation
|
group |
BEFREE |
To determine whether the c-mos oncogene has been translocated in AML-M2 with this translocation and to isolate DNA sequences and genes from these two chromosomes that may be important in malignancy, we constructed somatic cell hybrids between a Chinese hamster ovary cell (CHO) mutant defective in glycine metabolism and myeloblasts with an 8;21 translocation from a patient with AML.
|
2982159 |
1985 |
leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mos and c-myc, have also been mapped to chromosome 8.
|
3840278 |
1985 |
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Structure of the human c-mos protooncogene in DNAs from breast tumors, leukemic cells, and lymphocytes from normal individuals was analyzed by restriction enzyme digestion and Southern blot.
|
2996003 |
1985 |
Myeloid Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification in several human myeloid leukemias or cell lines of a DNA rearrangement next to the c-mos 3'-end.
|
2993032 |
1985 |
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mos and c-myc, have also been mapped to chromosome 8.
|
3840278 |
1985 |
Liver carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation state of cellular oncogenes (c-oncs) and epidermal growth factor (EGF) receptor gene from human liver tissues was examined by means of restriction endonuclease analysis. c-myc and EGF receptor gene from hepatocellular carcinoma and fetal liver were substantially hypomethylated in comparison with those genes from normal liver, while the extents of methylation of c-mos and c-Ki-ras genes were the same among these tissues.
|
3005205 |
1985 |
Leukemia, Myelocytic, Acute
|
0.050 |
Biomarker
|
disease |
BEFREE |
Another protooncogene, c-mos, is also retained at the conserved junction, suggesting that one or both of these genes may play a role in the pathogenesis of acute myelogenous leukemia.
|
3021321 |
1986 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human melanocytes infected with Ki-MSV or Ha-MSV, but not amphotropic MuLV, undergo a series of transformation-related changes that are characteristic of malignant melanoma.
|
2430046 |
1986 |
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
A single point mutation responsible for c-mos polymorphism in cancer patients.
|
2894001 |
1987 |
Leukemia, Myelocytic, Acute
|
0.050 |
Biomarker
|
disease |
BEFREE |
The findings in the former patient suggest that either c-mos is not involved in the etiology of M2-ANLL or, alternatively, if c-mos is important in the pathogenesis of this disease, it must be activated by some mechanism other than transposition of this oncogene to an aberrant position.
|
3466666 |
1987 |
Primary malignant neoplasm
|
0.050 |
GeneticVariation
|
group |
BEFREE |
A single point mutation responsible for c-mos polymorphism in cancer patients.
|
2894001 |
1987 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
In the case of Ha-MSV-containing constructs stably integrated in the two human breast cancer lines, however, CAT expression was more than two orders of magnitude greater than that transiently expressed in these cells.
|
2825673 |
1987 |
leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Localization of the human c-mos gene by in situ hybridization in two cases of acute nonlymphocytic leukemia type M2.
|
3466666 |
1987 |
leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A rare EcoRI restriction fragment length polymorphism (RFLP) in the 3' end of the human c-mos locus has been identified in DNA from patients with breast tumors, esophageal carcinomas and leukemias.
|
2894001 |
1987 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the case of Ha-MSV-containing constructs stably integrated in the two human breast cancer lines, however, CAT expression was more than two orders of magnitude greater than that transiently expressed in these cells.
|
2825673 |
1987 |
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
A rare EcoRI restriction fragment length polymorphism (RFLP) in the 3' end of the human c-mos locus has been identified in DNA from patients with breast tumors, esophageal carcinomas and leukemias.
|
2894001 |
1987 |
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Although this result is currently a matter of controversy, further studies must be independently repeated to be conclusive; -- another RFLP was found in c-mos proto-oncogene, which is detected only in patients with breast cancers or other types of tumors.
|
2905174 |
1988 |