|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML.
|
29241762 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Because MPL is expressed on hematopoietic cells, eltrombopag use in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) might enhance leukemic proliferation.
|
28473904 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Analysis of primary AML patient samples revealed a correlation between MPL and Bcl-xL expression specifically in t(8;21) blasts.
|
22337712 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
Hence, this study provides evidence that up-regulation of wild-type MPL levels promotes leukemia development and maintenance through activation of the PI3K/AKT axis, and suggests that inhibitors of this axis could be effective for treatment of MPL-positive AML.
|
22613795 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, CD110 and CD33 reactivity may be useful to distinguish APL from NPM-mutated AML with CD15, CD34 and HLA-DR negativity.
|
21812014 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, the MPL T487A mutation, identified in de novo acute myeloid leukemia, was not detected in 172 patients with a myeloproliferative neoplasm.
|
20823136 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-MPL was associated with CD34+ AML and M2 FAB AML subtype.
|
19097174 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.
|
15741216 |
2005 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Analysis of thrombopoietin receptor (c-mpl) mRNA expression in de novo acute myeloid leukemia.
|
10785262 |
2000 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that c-mpl protein overexpression in AML may play a role in the aggressiveness of this disease.
|
9933137 |
1999 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To address this concern, we studied the expression of c-mpl mRNA and c-Mpl protein by blasts from AML patients.
|
9711904 |
1998 |
|
Leukemia, Myelocytic, Acute
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|