|
Malignant neoplasm of prostate
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Decreased expression of prostatic secretory protein PSP94 in prostate cancer.
|
7506990 |
1993 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Urinary MSMB was better than urinary PSA at differentiating men with prostate cancer at all Gleason grades.
|
20967219 |
2010 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the current study, we have examined the effect of PSP-94 on prostate cancer growth and experimental metastases to the skeleton.
|
12727822 |
2003 |
|
Malignant neoplasm of prostate
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The presence of cells that express the beta-MSP transcript may be a novel indicator of potentially aggressive prostate cancer.
|
10075007 |
1999 |
|
Malignant neoplasm of prostate
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Together with the human data, this suggested that MSMB expression defines an anatomical domain in the mouse prostate that is molecularly most similar to human prostate cancers.
|
17244021 |
2007 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Additionally, 6 pathways were identified based on identified variants and genes, including estrogen signaling pathway, signaling by MST1, IL-15 production, MSP-RON signaling pathway, and IL-12 signaling and production in macrophages, which are known to be associated with prostate cancer.
|
31748686 |
2019 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Effect of androgen deprivation therapy on the expression of prostate cancer biomarkers MSMB and MSMB-binding protein CRISP3.
|
20680031 |
2010 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Comparison of prostate-specific promoters and the use of PSP-driven virotherapy for prostate cancer.
|
23484134 |
2013 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.
|
20717903 |
2011 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our data also demonstrated that HGF/c-Met, but not the MSP-RON signaling pathway may be the dominant mechanism for PCa EMT.
|
28440432 |
2017 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
PSP94 has shown potential to be a serum biomarker for evaluating prostate cancer.
|
9136077 |
1997 |
|
Malignant neoplasm of prostate
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The present study also shows that PSP94 is downregulated in different grades of prostate cancers.
|
10477906 |
1999 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the amount or nature of mRNA transcripts expressed from the LMTK2, HNF1B and MSMB candidate genes is altered in prostate cancer, and provides further evidence for a role for these genes in this disorder.
|
20569440 |
2010 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent functional work has shown that different alleles of the significantly associated SNP in the promoter of MSMB found to be associated with prostate cancer risk, rs10993994, can influence its expression in tumors and in vitro studies.
|
19644707 |
2009 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that MSMB is unlikely to be a familial PrCa gene and propose that the high-risk alleles of the SNPs in the 5'UTR effect PrCa risk by modifying MSMB gene expression in response to hormones in a tissue-specific manner.
|
19997100 |
2010 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We examined the association between rs10993994 genotype and MSP levels in a sample of 500 prostate cancer-free men from four racial/ethnic populations in the Multiethnic Cohort (European Americans, African Americans, Latinos, and Japanese Americans).
|
20736317 |
2010 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our objective was to determine the gene expression pattern of the SFRP family in prostatic cell lines and fresh frozen tissues from normal prostates (NP), benign prostatic hyperplasia (BPH) and prostate cancer (PCa), by qRT-PCR, and their DNAme status by MSP and bisulfite sequencing.
|
27570179 |
2016 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target.
|
19050691 |
2009 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
A peak at m/z 10,760 was identified as β-microseminoprotein (β-MSMB) and found to be statistically lower in urine from PCa participants using the peak's average areas.
|
24115268 |
2014 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility.
|
19383797 |
2009 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
Previous studies have suggested a potential biomedical utility of PSP94 in applications such as diagnosis/prognosis and in treatment of human prostate cancer (PCa).
|
17468008 |
2007 |
|
Malignant neoplasm of prostate
|
0.700 |
Biomarker
|
disease |
BEFREE |
The methylation of GSTP1 and RASSF1A was investigated by using the MSP in 50 prostate cancer and 17 benign prostate hyperplasia specimens.
|
25577235 |
2015 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that the increase in PC risk associated with rs10993994:C>T is likely mediated by the variant's effect on PSP94 expression; however, this effect does not extend to NCOA4 in the data presented here.
|
22887727 |
2013 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
SNPs in MSMB and 8q24 which predispose to prostate cancer overall are associated with risk for metastatic prostate cancer, the most lethal form of this disease.
|
21343373 |
2011 |
|
Malignant neoplasm of prostate
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure.
|
23608167 |
2013 |