MSMB, microseminoprotein beta, 4477

N. diseases: 195; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2677821
Disease: Prostate Cancer, Hereditary, 13
Prostate Cancer, Hereditary, 13
0.400 SusceptibilityMutation disease CLINVAR
CUI: C2677821
Disease: Prostate Cancer, Hereditary, 13
Prostate Cancer, Hereditary, 13
0.400 Biomarker disease CTD_human
CUI: C4025231
Disease: Chronic calcifying pancreatitis
Chronic calcifying pancreatitis
0.010 AlteredExpression disease BEFREE It was concluded that PSP-S gene expression is specifically reduced in CCP patients. 2525567 1989
CUI: C3714509
Disease: Nutrition Disorders
Nutrition Disorders
0.010 Biomarker group BEFREE Composition of calculi--at least 95% calcium salts and a degraded form of lithostathine S (formerly called PSP S2-5)--was similar in the Occidental alcoholic and in the tropical form: calcified calculi are probably related to alcohol and nutritional disorders. 1736346 1992
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 AlteredExpression disease BEFREE Decreased expression of prostatic secretory protein PSP94 in prostate cancer. 7506990 1993
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression disease BEFREE Decreased expression of prostatic secretory protein PSP94 in prostate cancer. 7506990 1993
CUI: C0024530
Disease: Malaria
Malaria
0.100 Biomarker disease BEFREE Structural diversity in a 45 kDa surface antigen on Plasmodium falciparum merozoites (termed GYMSSA, MSP-2 or MSA-2) and other candidate molecules for developing a malaria vaccine need to be investigated in parasites obtained directly from patients in different malaria endemic countries. 7918680 1994
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute
0.010 Biomarker disease BEFREE Decreased hepatic HGFL/MSP production might cause impaired Kupffer cell phagocytosis in fulminant hepatic failure. 7912298 1994
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker disease BEFREE PSP94 has shown potential to be a serum biomarker for evaluating prostate cancer. 9136077 1997
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 Biomarker disease BEFREE Prostate secretory protein of 94 amino acids (PSP94) has shown the potential to be a diagnostic biomarker and a therapeutic agent for prostate cancer. 9174167 1997
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker disease BEFREE PSP94 is a potential biomarker for evaluating patients with prostate carcinoma. 9136076 1997
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker disease BEFREE PSP94 has shown potential to be a serum biomarker for evaluating prostate cancer. 9136077 1997
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 Biomarker disease BEFREE Prostate secretory protein of 94 amino acids (PSP94) has shown the potential to be a diagnostic biomarker and a therapeutic agent for prostate cancer. 9174167 1997
CUI: C2747816
Disease: Complicated malaria
Complicated malaria
0.020 GeneticVariation disease BEFREE No specific genetic make-up was associated with severity; there were, however, marked differences in allele frequencies in both groups, with a prevalence up to 60% of MSP-2 alleles specifically observed in the severe malaria isolates. 9015525 1997
CUI: C0007095
Disease: Carcinoid Tumor
Carcinoid Tumor
0.010 AlteredExpression phenotype BEFREE HGFL/MSP mRNA is low to undetectable in human SCLC and carcinoid tumors, but the HGFL/MSP tyrosine kinase receptor, RON, is present and functional on many of these neuroendocrine tumors. 9185522 1997
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung
0.010 AlteredExpression disease BEFREE HGFL/MSP mRNA is low to undetectable in human SCLC and carcinoid tumors, but the HGFL/MSP tyrosine kinase receptor, RON, is present and functional on many of these neuroendocrine tumors. 9185522 1997
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors
0.010 AlteredExpression group BEFREE HGFL/MSP mRNA is low to undetectable in human SCLC and carcinoid tumors, but the HGFL/MSP tyrosine kinase receptor, RON, is present and functional on many of these neuroendocrine tumors. 9185522 1997
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 AlteredExpression disease BEFREE Our results showed a lower level of expression of beta-MSP in prostate cancer tissue, compared with benign prostate tissue. 9568674 1998
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.570 AlteredExpression group BEFREE We analyzed the expression of both beta-MSP mRNA and its protein in a large sample of prostate tumors from 104 patients with untreated prostate cancer, using both nonradioactive in situ hybridization (ISH) and IHC. 9568674 1998
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.200 AlteredExpression disease BEFREE Our results showed a lower level of expression of beta-MSP in prostate cancer tissue, compared with benign prostate tissue. 9568674 1998
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma
0.030 Biomarker disease BEFREE MSP and RON could also constitute an autocrine/paracrine system in human NSCLC cell lines: five of 16 cell lines (squamous and adenosquamous) expressed both MSP and RON; and an additional five of 16 cell lines expressed RON without detectable MSP. 9533936 1998
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate
0.020 Biomarker disease BEFREE Detection of PSP94 and its specific binding sites in the prostate adenocarcinoma cell line LNCaP. 9817377 1998
CUI: C4543807
Disease: Clinical malaria
Clinical malaria
0.020 GeneticVariation disease BEFREE The finding of an association between reduced risk of clinical malaria and infection with parasites of merozoite surface protein 1 (MSP-1) type RO33 or MSP-2 type 3D7 further suggests that the concomitant immunity is, at least in part, a consequence of a response to these major merozoite surface proteins. 9463681 1998
Human anaplasmosis due to Anaplasma phagocytophilum
0.010 AlteredExpression disease BEFREE Recombinant MSP-2B protein and an MSP-2A fusion protein were expressed in Escherichia coli and reacted with human sera positive for the HGE agent by immunofluorescence assay. 9673253 1998
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.700 AlteredExpression disease BEFREE The presence of cells that express the beta-MSP transcript may be a novel indicator of potentially aggressive prostate cancer. 10075007 1999