|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between CDH1 and MSX1 gene polymorphisms and the risk of nonsyndromic cleft lip and/or cleft palate in a southeast Iranian population.
|
23231047 |
2013 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between NSOC and rs3821949 or rs12532 in MSX1 gene, whereas an association was observed between the P147Q variant and cleft lip with cleft palate in the case-control analysis.
|
21689018 |
2011 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We pointed to: (i) a role of FOXE1 in controlling the expression of MSX1 and TGF-β3 relevant in craniofacial development and (ii) a causative part of FOXE1 mutations or mice Foxe1(-/-) genotype in the pathogenesis of cleft palate in the Bamforth-Lazarus syndrome.
|
21177256 |
2011 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice.
|
19934017 |
2009 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some genes affecting early tooth development (MSX1, AXIN2) are associated with tooth agenesis and systemic features (cleft palate, colorectal cancer).
|
18499550 |
2008 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results are consistent with evidence from other studies in the US and Chile and confirm the importance of the MSX1 genotype in determining the risk of CL/P and CP in Koreans.
|
17326252 |
2007 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
Defective growth in the anterior palate of Msx1-/- and Fgf10-/- mice leads to a complete cleft palate and supports the anterior-to-posterior direction of palatal closure.
|
16313398 |
2005 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since the Msx1 mouse knockout has cleft palate and MSX1 mutations have been found in rare cases of syndromic CL/P, this locus is especially plausible for linkage.
|
14755461 |
2004 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Genetic and experimental approach to bony craniofacial growth: the role of the divergent homeobox gene Msx1].
|
15301380 |
2003 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
CTD_human |
Transgenic rescue of the cleft palate of Msx1(-/-) mice overcame the neonatal lethality and allowed Msx1(-/-) mice to grow into adulthood but retain the phenotype of the absence of the malleal processus brevis.
|
12701100 |
2003 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
With likelihood ratio test analysis, "cleft lip only" showed association with MSX1 (p = 0.04) and "cleft palate only" with TGFB3 (p = 0.02).
|
12651933 |
2003 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MSX1 has been proposed as a gene in which mutations may contribute to non-syndromic forms of cleft lip and/or cleft palate.
|
12807959 |
2003 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Transgenic expression of human Bmp4 driven by the mouse Msx1 promoter in the Msx1(-/-) palatal mesenchyme rescued the cleft palate phenotype and neonatal lethality.
|
12163415 |
2002 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
CTD_human |
Transgenic expression of human Bmp4 driven by the mouse Msx1 promoter in the Msx1(-/-) palatal mesenchyme rescued the cleft palate phenotype and neonatal lethality.
|
12163415 |
2002 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prior studies have implicated an involvement of the Msx1 homeobox gene in cleft palate in mice and its homolog in humans (called MSX1 in the HOX7 gene, located on chromosome 4).
|
11332647 |
2001 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated potential associations between CL+/-P and CP and two putative clefting susceptibility loci, MSX1 and TGFB3, using data from a nationwide case-control study conducted in Denmark from 1991 to 1994.
|
11384957 |
2001 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MSX1 also showed significant evidence of linkage disequilibrium with a susceptibility gene controlling risk for CP.
|
11454503 |
2001 |
|
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By comparison, risk estimates for maternal alcohol consumption (> or = 4 drinks/month) were significantly elevated for CLP and were most elevated among infants with allelic variants at the MSX1 site.
|
9988882 |
1999 |
|
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Msx1-/Msx1- phenotype is similar to human cleft palate, and provides a genetic model for cleft palate and oligodontia in which the defective gene is known.
|
7914451 |
1994 |