COX1, cytochrome c oxidase subunit I, 4512

N. diseases: 421; N. variants: 89
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE In the present study, COX‑1 was identified to be markedly upregulated in colorectal tissues of patients with CRC, and in the CRC cell lines HCT116 and HT29. 30320345 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE In total, 50 colorectal cases including 10 control cases of colectomy for non-neoplastic condition, 15 cases of adenomatous colorectal polyps, and 25 cases of colorectal carcinoma were investigated in this retrospective study for immunohistochemical expression of CcOI. 28362707 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE Noticeably, the expression of MT-COI was overexpressed in late colorectal carcinomas among all studied transcripts. 27333991 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 Biomarker disease BEFREE EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer. 24171795 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 GeneticVariation disease BEFREE After ginger consumption, participants at increased risk for CRC had a significantly reduced colonic COX-1 protein level (23.8±41%) compared with the placebo group (18.9±52%; P=0.03). 23222413 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 GeneticVariation disease UNIPROT A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase. 19218458 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 GeneticVariation disease UNIPROT Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. 16407113 2006
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE To cast light on the role(s) of COX enzymes in the development and progression of colorectal cancers and to determine the incidence of COX-2 overexpression, the expression levels of COX-1 and COX-2 proteins using Western blot analysis in tumor tissues and adjacent normal tissues obtained from 44 Thai patients with colorectal cancer. 15075004 2004
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE Both gastrin and CCK(B)-R mRNA were detected in the cancer tissue and resection margin by RT-PCR, and similarly, COX-1 and COX-2 mRNA were expressed in these tissues of most CRCs. 12353842 2002
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 Biomarker disease BEFREE Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells. 11062695 2000
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 Biomarker disease BEFREE Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. 9589912 1998
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 AlteredExpression disease BEFREE COX-1 and COX-2 messenger RNA (mRNA) levels were determined by Northern blot analysis of poly(A)+ RNA isolated from human colorectal cancers, adenomas, and accompanying normal mucosa. 7926468 1994
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.500 CausalMutation disease CLINVAR