|
Anorexia Nervosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
These changes, supported by altered mRNA levels of genes coding for enzymes involved in eiCs-related methabolic pathways (i.e., PLA<sub>2</sub>, COX-2, 5-LOX and 15-LOX), underlie a widespread brain dysregulation of pro- and anti-inflammatory eiC-mediated processes in the ABA model of AN.
|
31778792 |
2020 |
|
Corneal Ulcer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study focused on the molecular identification of Pythium insidiosum from patients with corneal ulcer using ITS regions and clade identification by cox II gene sequencing and correlated with the clinical outcome.
|
31073609 |
2020 |
|
Cardiac Arrest
|
0.010 |
Biomarker
|
disease |
BEFREE |
We explored this hypothesis in our swine model of Cardiac Arrest (CA) which involves global I/R with pretreatment using a predominantly COX-1 inhibitor (Indomethacin [COX-1/min COX-2 Inh], a COX-2 Inhibitor [COX-2-Inh, (Celecoxib)] or placebo control.
|
31734378 |
2020 |
|
Allergy to metal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, the inhibition of COX-2 may be a therapeutic target for Cr allergy, and additional molecules in the PGE<sub>2</sub> signalling pathway may also be an effective therapeutic target for the treatment of metal allergy.
|
31587584 |
2020 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
COX-2 Inhibitors, Aspirin, and Other Potential Anti-Inflammatory Treatments for Psychiatric Disorders.
|
31214060 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the relative contribution of COX-2 and COX-1 isoforms in the downstream proinflammatory responses and cognitive deficit in HH remains unknown.
|
30476507 |
2019 |
|
Contracture of joint
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture.
|
31410880 |
2019 |
|
Dermatitis, Atopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with AD may experience immune imbalance, increased levels of mast cells, immunoglobulin (Ig) E and pro-inflammatory factors (Cyclooxygenase, COX-2 and inducible NO synthase, iNOS).
|
31137528 |
2019 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we evaluate the efficacy of COX-2 inhibition and VEGF blockade in preclinical models of PDA.
|
30333153 |
2019 |
|
Dysmenorrhea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
For that purpose, the expression levels of LOX‑5, COX‑2, interleukin (IL)‑6 and IL‑8 in the EU and EC of patients with adenomyosis were determined, and clinical data including dysmenorrhea and menstruation were analyzed.
|
30387822 |
2019 |
|
Eczema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with AD may experience immune imbalance, increased levels of mast cells, immunoglobulin (Ig) E and pro-inflammatory factors (Cyclooxygenase, COX-2 and inducible NO synthase, iNOS).
|
31137528 |
2019 |
|
Epithelial cyst
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
COX-2 and/or cPLA2 inhibition might prevent the emergence or progression of mucinous pancreatic cysts, but higher doses of ASA or nonsteroidal anti-inflammatory drugs may be necessary to substantially inhibit cyst epithelial COX-2 activity.
|
31009406 |
2019 |
|
Graft-vs-Host Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cox-2 expression in the GVHD-targeted organs of WT mice is increased upon GVHD induction, but this enhanced expression was obviously inhibited by MyD88 deficiency.
|
30317551 |
2019 |
|
Lichen disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The values of RMSD, Rg, and interaction energy after 30 ns of MDS revealed the good stability of these Lichen compounds in the active site pocket of Cox-2 in compare to reference, JMS.
|
31524074 |
2019 |
|
Lichen Planus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to investigate the effects of prednisolone and acitretin treatments on Ki-67, Bcl-2, and COX-2 expression and apoptosis in patients with LP and the role of Ki-67, Bcl-2, and COX-2 proteins in LP.
|
31218676 |
2019 |
|
Marek Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we could demonstrate that MDV infection activates the COX-2/prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) pathway, as evident by increased levels of arachidonic acid, COX-2 expression, and PGE<sub>2</sub> synthesis.
|
30971474 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The Relationship of COX-2 Gene Polymorphisms and Susceptibility to Kawasaki Disease in Chinese Population.
|
30321073 |
2019 |
|
Osteoarthropathy, Primary Hypertrophic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we reported the first case of HPGD mutated PHO patient with soft tissue giant tumors at lower legs and evaluated the efficacy of selective COX-2 inhibitor (Etorcoxib) treatment in the patient.
|
31063976 |
2019 |
|
Cartilaginous exostosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
COX-2 protein expression in osteosarcoma was higher than in benign osteochondroma (OR = 7.66, <i>P </i><<i> </i>0.001).
|
30761249 |
2019 |
|
Pancreatic Cyst
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
COX-2 and cPLA2 are overexpressed in the epithelium of mucinous pancreatic cysts.
|
31009406 |
2019 |
|
Photosensitivity Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
<b>Conclusion:</b> It can be stated that melatonin included in the newly formulated sunscreen was able to inhibit the induction of photodermatitis via immunoregulation of inflammatory cytokines along with NF-κB and COX-2 genes.
|
30741582 |
2019 |
|
Radicular Cyst
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast with the controls, the ratio of EDA + FN/total FN in the fibroblasts from radicular cysts was significantly higher (p < 0.05), and positively associate with Trap + MNCs counting, it was consistent with increased expression of COX-2, IL-6, IL-17, and the RANKL/OPG (p < 0.05).
|
30770599 |
2019 |
|
Unipolar Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The COX-2 inhibitor celecoxib was found to have a significant positive effect on major depression, not only in single studies but also in meta-analyses.
|
31214060 |
2019 |
|
Tachycardia, Ventricular
|
0.010 |
Biomarker
|
disease |
BEFREE |
In macrophages stimulated by LPS, expression of the inflammatory factors iNOS, COX-2, and NO production increased, while the r-fp-151-VT-treated groups had suppressed expression of iNOS, COX-2, and NO production in a dose-dependent manner.
|
30188221 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma.
|
31187468 |
2019 |