COX2, cytochrome c oxidase subunit II, 4513

N. diseases: 875; N. variants: 79
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 Biomarker group BEFREE Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan. 29385156 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 GeneticVariation group BEFREE To determine the association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in elderly adults with diabetes. 24342014 2014
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 Biomarker group BEFREE The products of COX-2 and LOX activities have been implicated in cytokine-mediated damage of beta-cells, so selective inhibitors of these enzymes would be expected to have a dual protective role in diabetes: they would minimize beta-cell dysfunction while maintaining insulin secretion through enhancing endogenous arachidonic acid levels. 17192482 2007
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 Biomarker group BEFREE Combination of COX-2 inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan. 31593087 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 AlteredExpression group BEFREE Our results demonstrated that expression of IL-6 and COX-2 were remarkably up-regulated in peripheral blood of DMCI patients compared with that in normal control group. 29511456 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 AlteredExpression group BEFREE Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus. 30498345 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.160 Biomarker group HPO