Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.360 GeneticVariation disease BEFREE In our study, we aimed to investigate the relationship between variants of COX-2 gene which is one of the key components of the inflammatory pathway, and T2DM risks. 30293595 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.360 GeneticVariation disease BEFREE Patients who have OA and T2DM receiving combination COX-2 inhibitors and metformin therapy associated with lower joint replacement surgery rates than those without and this may be attributable to combination therapy much more decrease pro-inflammatory factors associated than those without metformin therapy. 29385156 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.360 GeneticVariation disease BEFREE Cox proportional hazard regression analysis revealed the lower rate of admission for subjects under combination therapy (adjusted hazard ratio of 0.275; 95% confidence interval = 0.136-0.557, P < .001).Patients with RA and T2DM receiving the combination of COX-2 inhibitors and metformin were associated with lower admission rate than those on COX-2 inhibitors alone, and this effect may be attributed to the decrease in the levels of proinflammatory factors. 31593087 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.360 Biomarker disease BEFREE Glycolytic (PKM1, PKM2, and ENO1) and mitochondrial (MTCO2) enzymes were significantly elevated in glomeruli of CKD- versus CKD+ individuals with type 2 diabetes. 31076418 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.360 Biomarker disease BEFREE Our results suggested that the inhibition of COX2/PGD2-related autophagy was involved in the mechanism of brain injury caused by type 2 diabetes in rats. 30873010 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.360 AlteredExpression disease BEFREE COX-2 expression was significantly enhanced in human T2DM islets, correlated with the high inflammation level. 31105125 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.360 Biomarker disease HPO
Diabetes Mellitus, Non-Insulin-Dependent
0.360 Biomarker disease RGD Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. 14563825 2004