COX2, cytochrome c oxidase subunit II, 4513

N. diseases: 875; N. variants: 79
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease BEFREE These findings suggest that selective inhibition of COX-2 ameliorates depression-like behaviors in rat models of depression. 31539536 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 AlteredExpression disease BEFREE 1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression. 31022424 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease BEFREE Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. 28108057 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease BEFREE Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression. 30526621 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease PSYGENET There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease BEFREE There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease PSYGENET The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. 22331023 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease PSYGENET Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 GeneticVariation disease BEFREE Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease PSYGENET Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. 20034614 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease PSYGENET Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients. 20588070 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 AlteredExpression disease BEFREE COX-2 overexpression was observed in 12 of 77 (15.6%) DP and there was no significant difference between DPdep (3 of 23, 13.0%) and DPpo (9 of 54, 16.7%). 12397273 2002
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.470 Biomarker disease HPO