COX2, cytochrome c oxidase subunit II, 4513

N. diseases: 875; N. variants: 79
Disease: Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever 		0.160 Biomarker phenotype BEFREE In addition, COX-2 in myeloid and neural cells was dispensable for the fever response. 27940259 2017
CUI: C0015967
Disease: Fever
Fever 		0.160 Biomarker phenotype BEFREE Mechanistically, RANKL activates brain regions involved in thermoregulation and induces fever via the COX2-PGE(2)/EP3R pathway. 19940926 2009
CUI: C0015967
Disease: Fever
Fever 		0.160 AlteredExpression phenotype BEFREE Exposure to hyperthermia reduces IL-1beta-induced prostaglandin E2 release, suppresses activation of the adhesion molecules VCAM-1, ICAM-1, the cytokines TNFalpha, IL-1alpha, IL-1beta, IL-8 as well as COX-2 protein synthesis. 16955275 2006
CUI: C0015967
Disease: Fever
Fever 		0.160 Biomarker phenotype BEFREE We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever. 15161979 2004
CUI: C0015967
Disease: Fever
Fever 		0.160 GeneticVariation phenotype BEFREE Thus, COX-2-selective drugs or null mutation of the COX-2 gene reduce or prevent fever. 11113025 2000
CUI: C0015967
Disease: Fever
Fever 		0.160 Biomarker phenotype BEFREE It is clear that COX-2 is the isoform responsible for production of the PGs that mediate inflammation, pain, and fever. 10643694 2000
CUI: C0015967
Disease: Fever
Fever 		0.160 Biomarker phenotype HPO