Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For MTHFD1 rs2236225 polymorphism, mothers having GA genotype and A allele exhibited an increased risk of NTDs in the offspring (OR = 2.600, 95%CI: 1.227-5.529; OR = 1.847, 95%CI: 1.047-3.259).
|
30867013 |
2019 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
For rs2236225 within MTHFD1, children with allele A or genotype AA had a high NTDs risk (OR=1.500, 95%CI=1.061~2.120; OR=2.862, 95%CI=1.022~8.015, respectively).
|
29392422 |
2018 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our research provides the first evidence supporting a paternal, rather than a maternal, transmission bias of MTHFD1 G1958A variant for NTD susceptibility in the offspring.
|
26394717 |
2016 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Statistical and bioinformatics analyses were performed to investigate the relationship between SNPs in MTHFD1 and susceptibility to NTDs.
|
26343515 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In our study, an increased risk of NTD was observed for 1958G>A of MTHFD1 (AA vs. GG: OR=2.63, 95% CI=2.61-5.70; AA vs. GG+GA: OR=2.10, 95% CI=1.07-4.14; A vs. G: OR=1.62, 95% CI=1.11-2.36).
|
25524527 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the present meta-analysis provided evidence of the association between maternal MTHFD1 G1958A polymorphism and NTD susceptibility.
|
25502174 |
2015 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results demonstrated a significant correlation between the MTHFD1 G1958A polymorphism and NTDs in an overall meta-analysis.
|
24977710 |
2014 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MTHFD1 p.R653Q has been proposed as a risk factor for neural tube defects (NTDs), congenital heart defects (CHDs) and pregnancy losses.
|
23704330 |
2013 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Gene variants in the folate metabolic pathway (e.g., MTHFR rs1801133 (677 C > T) and MTHFD1 rs2236225 (rs2236225" genes_norm="1788;4522">R653Q)) have been found to increase NTD risk.
|
22856873 |
2012 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A common variant in MTHFD1, p.Arg653Gln (c.1958G>A), may increase the risk for neural tube defects (NTD).
|
18767138 |
2009 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
Having previously identified a polymorphism within the cytoplasmic folate enzyme, MTHFD1, as a maternal risk factor for NTDs, we considered the more recently identified mitochondrial paralogue, MTHFD1L, as a candidate gene for NTD association.
|
19777576 |
2009 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Analysis of the MTHFD1 promoter and risk of neural tube defects.
|
19130090 |
2009 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
LHGDN |
In summary, our results indicate that heterozygosity and homozygosity for the MTHFD1 1958G > A polymorphism are genetic determinants of NTD risk in the cases examined.
|
16315005 |
2006 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population.
|
16552426 |
2006 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In summary, our results indicate that heterozygosity and homozygosity for the MTHFD1 1958G > A polymorphism are genetic determinants of NTD risk in the cases examined.
|
16315005 |
2006 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
CTD_human |
We have established that the MTHFD1 1958G>A polymorphism has a significant role in influencing a mother's risk of having an NTD-affected pregnancy in the Irish population.
|
16552426 |
2006 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that genetic variation in the MTHFD1 gene is associated with an increase in the genetically determined risk that a woman will bear a child with NTD and that the gene may be associated with decreased embryo survival.
|
12384833 |
2002 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
CTD_human |
We conclude that genetic variation in the MTHFD1 gene is associated with an increase in the genetically determined risk that a woman will bear a child with NTD and that the gene may be associated with decreased embryo survival.
|
12384833 |
2002 |
Neural Tube Defects
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A selected number of SBA patients was additionally tested for specific mutations in MTHFD, FRalpha, and PAX1 already shown to be related to NTD.
|
11320527 |
2001 |
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
BEFREE |
Our results so far provide no evidence for a major role of the methylenetetrahydrofolate-dehydrogenase (MTHFD) gene in NTD etiology.
|
9611072 |
1998 |