|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion:</b> Our results showed that the MTHFR [677C>T (rs1801133)] TT genotype is associated with ADRs to MTX in Chinese RA patients.
|
30546311 |
2018 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Higher serum B12 levels and decreased frequency of the MTHFR 677TT variant in RA patients could potentially account for the observed differences between the groups.
|
29501539 |
2018 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CT genotype and T allele of MTHFR C677 T and GG genotype and G allele of LT-α A252G are associated with the risk of RA and with higher levels of the pro-inflammatory cytokine, TNF-α in patients with rheumatoid arthritis.
|
27692391 |
2018 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T polymorphism was associated with HHC in RA patients (multi-adjusted OR, 95% CI 2.18, [1.07-4.57]; p = 0.031).
|
29796841 |
2018 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Pooled results showed that MTHFR gene A1298C polymorphism was not significantly related to MTX toxicity or efficacy in RA patients.
|
28544525 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
C677T MTHFR gene polymorphism is associated with RA in Egyptians.
|
28215593 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of MTHFR 1298AA along with ADORA2A rs2298383 CC or CT genotypes occurring in one-third of RA patients showed a higher frequency of general nodules 15/59 (25.4%) as well as developing nodules during MTX treatment 13/59 (22.0%) in comparison with the overall studied group: 24/185 (13.0%) and 19/185 (10.3%), respectively.
|
27846189 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations between MTX response in RA patients in MTHFR 1298A > C (rs1801131), ATIC 347C > G (rs2372536), RFC-1 80G > A (rs1051266), SLC19A1 A > G (rs2838956) and SLC19A1 G > A (rs7499) genetic polymorphisms were found, but not observed between the MTHFR 677C > T (rs1801133), TYMS 28 bp VNTR (rs34743033), MTRR 66A > G (rs1801394), and ABCB1 3435C > T (rs1045642).
|
28266606 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.
|
28994615 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The absence of TYMS 1494 del6 and FPGS rs10106 and presence of MTHFR C677T predict adverse events in RA patients treated with MTX.
|
27992285 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the paucity of studies, especially in non-Asian populations, further studies with larger sample sizes are required to elucidate the role of MTHFR polymorphisms in the genetic basis of RA in different ethnic populations.
|
27423206 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The c.677 C > T and c.1298 A > C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C > T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients.
|
28299396 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis.
|
26599798 |
2016 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the MTHFR gene influence the effectiveness of methotrexate, the first line of therapy in RA.
|
27338350 |
2016 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the C677T polymorphism in the MTHFR gene is associated with MTX toxicity in Tunisian RA patients.
|
26077125 |
2016 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine the expression of MTHFR gene in patients with RA, with and without ischaemic heart disease (IHD).
|
26843177 |
2016 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several authors have reported contradictory results related to C677T polymorphism in the MTHFR gene and response to MTX in RA.
|
26314492 |
2015 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to the strong association between alleles of the HLA-DRB1*04 shared epitope and both subclinical and clinically evident CV disease, genes implicated in inflammation and metabolism, such as TNFA, MTHFR, and CCR5, seem to be associated with a higher risk of CV disease in patients with RA.
|
25163740 |
2015 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models.
|
26147289 |
2015 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment.
|
24967362 |
2014 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MEDLINE and EMBASE database searches and subsequent manual searches were utilized to identify articles in which C677T and A1298C MTHFR polymorphisms were evaluated in RA patients taking MTX.
|
24794492 |
2014 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTHFR SNPs rs1801131 and rs1801133 are unlikely to have a clinically meaningful effect on the first 6 months of MTX treatment in early RA.
|
24624914 |
2014 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the MTHFR C677T and IL-4 70bp VNTR variation in Turkish patients with RA and evaluate if there was an association with clinical features, especially ocular involvement, in RA patients.
|
23685257 |
2013 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cardiovascular events are not associated with MTHFR polymorphisms, but are associated with methotrexate use and traditional risk factors in US veterans with rheumatoid arthritis.
|
23547211 |
2013 |
|
Rheumatoid Arthritis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The available evidence suggests that the MTHFR C677T and A1298C gene polymorphisms are not reliable predictors of response to MTX treatment in RA patients.
|
21931346 |
2013 |