|
Obsessive-Compulsive Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder.
|
30992611 |
2020 |
|
Spinocerebellar Ataxia Type 2
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTHFR A1298C polymorphism is associated with saccade latency in SCA2 patients, but not with disease risk, age at onset or maximal saccade velocity.
|
31812845 |
2020 |
|
Motor neuron atrophy
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In particular, we assessed the impact of MTHFR as rate-limiting enzyme in DNA methylation pathways, which modulates cerebellar neurotransmission and motor neuron atrophy.
|
31812845 |
2020 |
|
Schizophrenia, Childhood
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inconsistent with expectations, no significant associations were found between MTHFR C677T polymorphism and schizophrenia in children.
|
31302825 |
2019 |
|
Virus Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, there was no statistically significant association between MTHFR C677T polymorphism and viral infection, even considering hr-HPV or HPV 16 positivity.
|
31170928 |
2019 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Some common genes that are included in nutrition-based multigene test panels include CYP1A2 (rate of caffeine break down), MTHFR (folate usage), NOS3 (risk of elevated triglyceride levels related to omega-3 fat intake), and ACE (blood pressure response in related to sodium intake).
|
31254340 |
2019 |
|
Hemophilic arthropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The distribution of risk genotypes for MTHFR and TNFα-308GA suggests their association with clinical parameters of hemophilic arthropathy.
|
31566926 |
2019 |
|
Diabetic Polyneuropathies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Among patients with diabetic polyneuropathy, the status of folic acid, homocysteine, and nerve conduction studies (NCS) variations has been associated with methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms.
|
31143237 |
2019 |
|
Anterior myocardial infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and prothrombotic biomarkers in pulmonary embolism (PE) and acute myocardial ischemia (AMI).
|
29916259 |
2019 |
|
Acute myocardial ischemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim was to analyze the relationship between the C677T and A1298C polymorphisms of MTHFR, Hcy levels, and prothrombotic biomarkers in pulmonary embolism (PE) and acute myocardial ischemia (AMI).
|
29916259 |
2019 |
|
Vaso-Occlusive Crisis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation' and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population.
|
31440871 |
2019 |
|
Polyp of large intestine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The C/C genotype of MTHFR rs1801131 is more likely to be a genetic risk factor for colorectal polyps in the UK region, although this finding should be verified with a larger sample size.
|
31146742 |
2019 |
|
Hyalinosis, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found 4 positive sites for HFS in the TYMS and MTHFR genes: TYMS rs2606241 (P = 0.022), TYMS rs2853741 (P = 0.019), MTHFR rs3737964 (P = 0.029), and MTHFR rs4846048 (P = 0.030).
|
31601265 |
2019 |
|
Depression in children
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Serum cholesterol, MTHFR methylation, and symptoms of depression in children.
|
31621343 |
2019 |
|
Neonatal thrombosis of cerebral venous sinus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The Role of Factor V Leiden, Prothrombin G20210A, and MTHFR C677T Mutations in Neonatal Cerebral Sinovenous Thrombosis.
|
31025572 |
2019 |
|
Beckwith-Wiedemann Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTHFR rs1801133: C>T was more prevalent in BWS with KCNQ1OT1 TSS-DMR LOM (p < 0.017); however, the relationship was not significant when the Bonferroni correction for multiple testing was applied (significance, p = 0.0036).
|
30165906 |
2018 |
|
Drug abuse
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, significant interaction effects between childhood abuse experiences and the COMT and MTHFR genetic variants on the development of male homosexuality were found.
|
29289372 |
2018 |
|
Fanconi Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, there was no significant association between <i>MTHFR</i> C677T (rs1801133) or A1298C (rs1801131) polymorphisms and the clinical response to fluoropyrimidine-based chemotherapy under all of the three genetic models (allele model, dominant model, and recessive model) and stratification analysis, except for the retrospective study subgroup in the dominant model of <i>MTHFR</i> C677T and the "5-Fu <i>+</i> FA" treatment group in the allele contrast of <i>MTHFR</i> A1298C.
|
30131855 |
2018 |
|
Gonorrhea
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Researches exploring MTHFR polymorphisms C677T's relationship with the clinical outcomes (response rate, overall survival and toxicity) of GC patients treated with 5-Fu based chemotherapy were included.
|
29581785 |
2018 |
|
Subarachnoid Hemorrhage
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, frequency of MTHFR C677T genotype, CT (53% vs. 20%; p < 0.001) and TT (15% vs. 2%; p < 0.05) was significantly higher in SAH group as compared to healthy controls.
|
29926428 |
2018 |
|
Chronic pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We present the case of a patient with reduced <i>COMT</i> and <i>MTHFR</i> expression treated with leucovorin 10 mg daily for the management of chronic pain.
|
29317847 |
2018 |
|
Sensory neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using logistic regression with age and height as covariates, and uncorrected empirical p-values, genetic variation in SLC28A1, SAMHD1, MTHFR and RRM2B was associated with SN in South Africans using d4T.
|
30273369 |
2018 |
|
Subacute Combined Degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate Reductase (<i>MTHFR</i>) C677T Polymorphism and Subacute Combined Degeneration: Revealing a Genetic Predisposition.
|
30687218 |
2018 |
|
Paraparesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A>C AND c.677C>T MTHFR polymorphism: A case report.
|
30544400 |
2018 |
|
Breast Cancer, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, the less common haplotype MTHFR T-C was more frequent in young patients and in familial breast cancer, while MTHFR C-C haplotype was associated with sporadic BC form.
|
29544444 |
2018 |