Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TT genotype of MTHFR gene is associated with CHD, and a mother or a child with T allele has a much higher risk of CHD.
|
30334422 |
2019 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease.
|
31163415 |
2019 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (<i>MTHFR</i>) and methionine synthase reductase (<i>MTRR</i>) gene polymorphisms with the risk of congenital heart diseases (CHD).<b>Methods:</b> Eligible articles were searched in PubMed, Medline, Embase and CNKI.
|
30333252 |
2018 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to study associations between potential environmental risk factors and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in CHD.
|
29600076 |
2018 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Published studies indicated that the MTHFR gene polymorphisms C677T and A1298C are associated with congenital heart disease (CHD) risk in children, but obtained inconsistent results.
|
29554656 |
2018 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD.
|
28758112 |
2017 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, our present meta-analysis supports the MTHFR 1298C allele as a risk factor for CHD.
|
29202788 |
2017 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study results indicate that MTHFR gene 677T polymorphism is a genetic risk factor in the development of CHD in Chinese paediatric population.
|
28591039 |
2017 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
On multivariate analysis, the risk factors noted for CHD were presence of MTHFR C677→︀T among children and their mothers and MTRR A66→︀G among mothers.
|
28876333 |
2017 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of the current study was to explore the correlation between serum homocysteine (HCY) levels and the methylene tetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism and coronary heart disease (CHD).
|
27051002 |
2016 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genotypes of MTHFR C677T CC, CT, and TT were 9.52%, 49.66%, and 40.82% in CHD group but 29.17%, 50% and 20.83% in control group, which were identical using both methods of HRM and PCR-RFLP, demonstrating the sensitivity and specificity of HRM were all 100%.
|
26990189 |
2016 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians.
|
26095803 |
2015 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared with the mothers whose MTHFR were rs1801131 AA and AC genotypes, the mothers who got a mutation of MTHFR rs1801131 CC genotypes had a 267% increase in risk of given birth of a CHD children (OR = 3.67,95%CI = 1.12-12.05).
|
26035828 |
2015 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results from this study indicate that the MTHFR c.1625A>C genetic variant influences the risk of CHD in the studied population.
|
25494855 |
2015 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results support the MTHFR -677T allele as a susceptibility factor for CHD in the Asian maternal population and the -1298 C allele as a risk factor in the Caucasian paediatric population.
|
25472587 |
2014 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggested that the c.1333C > T genetic polymorphism of MTHFR gene was statistically associated with the increased risk of CHD [TT versus CC: odds ratio (OR) = 2.70, 95% confidence interval (CI) 1.34-5.45, p = 0.005; T versus C: OR = 1.38, 95% CI 1.03-1.86, p = 0.032].
|
24387084 |
2014 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population.
|
25124382 |
2014 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These preliminary findings indicate that these two MTHFR genetic polymorphisms are related with the risk of CHD in Chinese Han population, and might be potentially utilized as molecular markers.
|
24720776 |
2014 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious.
|
23876493 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Also, homocysteine levels were significantly increased with both MTHFR 677TT and 1298CC genotypes in Egyptian children with CHD.
|
23933414 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The multivariate logistic regression analysis confirmed that the MTHFR-CC genotype was associated with elevated BMI levels in diabetic CHD patients (odds ratio [OR] = 5.42, P = 0.003).
|
24218123 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous t-hromboembolism.
|
23288205 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Frequency of MTHFR G1793A polymorphism in individuals with early coronary artery disease: cross-sectional study.
|
24310797 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to analyze the possible association between the genotype 677T/T of the MTHFR gene and supplementation of FA in Mexican women with the presence of complex CHD in their children.
|
22660520 |
2013 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population.
|
24338416 |
2013 |