Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size.
|
30898617 |
2019 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk.
|
28968218 |
2017 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The association between depression and methylenetetrahydrofolate reductase (MTHFR) has been continually demonstrated in clinical studies, yet there are sparse resources available to build a relationship between the mutations associated with MTHFR and depression.
|
28427558 |
2017 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Focused interventions for those with higher homocysteine level and MTHFR TT genotype might reduce the risk of later depressive disorder.
|
27626182 |
2016 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).
|
26681493 |
2016 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distinct effects of folate pathway genes MTHFR and MTHFD1L on ruminative response style: a potential risk mechanism for depression.
|
26926881 |
2016 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study substantiates the involvement of the MAOA and MTHFR polymorphisms in climacteric depression and offers evidence that the COMT and ESR1 genes may also play a role in the susceptibility to depressive mood in postmenopausal women.
|
26620113 |
2016 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results support the homocysteine theory of depression and the safety and therapeutic benefit of reduced B vitamins as monotherapy for MDD, particularly in patients with MTHFR polymorphism.
|
27035272 |
2016 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Homocysteine and MTHFR C677T polymorphism in children and adolescents with psychotic and mood disorders.
|
23586533 |
2014 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
|
24532086 |
2014 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to examine whether the COMT-MTHFR genotype interacted with cognitive function in late-onset depression (LOD) patients and COMT Val/Val homozygous individuals who also carried the MTHFR T allele and had poor neuropsychological test performance.
|
24373005 |
2014 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
In this study, we aimed to examine whether the COMT-MTHFR genotype interacted with cognitive function in late-onset depression (LOD) patients and COMT Val/Val homozygous individuals who also carried the MTHFR T allele and had poor neuropsychological test performance.
|
24373005 |
2014 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
|
26177556 |
2014 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
|
24532086 |
2014 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
|
26177556 |
2014 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
|
23900311 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
Depressive disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
|
23116396 |
2013 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
|
22668858 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, we did find evidence to suggest that folic acid supplements during pregnancy protected against depression 21 months postpartum, and that this effect was more pronounced in those with the MTHFR C677T TT genotype (change in depression score from 8 months to 21 months postpartum among TT individuals was 0.66 (95% CI=0.31-1.01) among those not taking supplements, compared with -1.02 (95% CI=-2.22-0.18) among those taking supplements at 18 weeks pregnancy, P(difference)=0.01).
|
21772318 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).
|
23285094 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
|
22739363 |
2012 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T is associated with MA in individuals selected for depression study.
|
21635773 |
2011 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Stepwise multiple regression was used to determine the best statistical model to predict depression; C677T-MTHFR (p=0.0103) was found to be positively associated with depression, while the thiol dipeptide Cys-Gly was negatively associated (p=0.0403).
|
21125200 |
2010 |
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetet rahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
|
20163778 |
2010 |