MTHFR, methylenetetrahydrofolate reductase, 4524

N. diseases: 985; N. variants: 137
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE In this study, we aim to verify the correlation between MTHFR polymorphisms and clinical features of schizophrenia, while exploring the differential genomic methylation and disease related genes as the potential targets for schizophrenia. 31476590 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The three major MTHFR genotypes (G1793A, C677T, and A1298C) were examined in all subjects and the association between MTHFR polymorphism and clinical features of schizophrenia was analyzed. 31302825 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia. 29202425 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders. 30397195 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE MTHFR C677T increased schizophrenia risk in a dose-dependent manner per MTHFR T allele (P = 0.005) consequent upon CA exposure. 28556887 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE MTHFR A1298C polymorphism was found to be a risk factor for schizophrenia and might have played a significant role in the pathogenesis of schizophrenia. 28862175 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q. 28427558 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia. 27025471 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker disease BEFREE GRS based on three SNPs (CENPQ, CPS1, and MTHFR) was significantly associated with SCZ. 27810229 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE We conclude that MTHFR polymorphism is associated with SZ and BPD among Asian, African populations, but not the white. 24938371 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group. 23586533 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia. 24535549 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia. 24229535 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. 25101272 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study. 23353103 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE From this work, genetic variation within both the methylenetetrahydrofolate reductase (MTHFR) gene and the catechol-O-methyltransferase (COMT) gene has been associated with an increased risk of metabolic syndrome in schizophrenia patients treated with AAPs. 23341251 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our findings suggested that the MTHFR 677T allele might have effect on risk of schizophrenia, memory impairment and GMD changes in patients. 23318463 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our results indicated a strong association between MTHFR A1298C and schizophrenia. 22813657 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population. 23076983 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined. 22128864 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences. 22690662 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability? 21185933 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients. 21980405 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Folate supplementation in schizophrenia: a possible role for MTHFR genotype. 21334854 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE In conclusion, neither winter birth nor MTHFR genotype were significantly associated with increased schizophrenia risk. 21093223 2011