Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aim to verify the correlation between MTHFR polymorphisms and clinical features of schizophrenia, while exploring the differential genomic methylation and disease related genes as the potential targets for schizophrenia.
|
31476590 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The three major MTHFR genotypes (G1793A, C677T, and A1298C) were examined in all subjects and the association between MTHFR polymorphism and clinical features of schizophrenia was analyzed.
|
31302825 |
2019 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.
|
29202425 |
2018 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders.
|
30397195 |
2018 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T increased schizophrenia risk in a dose-dependent manner per MTHFR T allele (P = 0.005) consequent upon CA exposure.
|
28556887 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
MTHFR A1298C polymorphism was found to be a risk factor for schizophrenia and might have played a significant role in the pathogenesis of schizophrenia.
|
28862175 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q.
|
28427558 |
2017 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia.
|
27025471 |
2016 |
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
GRS based on three SNPs (CENPQ, CPS1, and MTHFR) was significantly associated with SCZ.
|
27810229 |
2016 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that MTHFR polymorphism is associated with SZ and BPD among Asian, African populations, but not the white.
|
24938371 |
2015 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group.
|
23586533 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia.
|
24535549 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia.
|
24229535 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.
|
25101272 |
2014 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study.
|
23353103 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
From this work, genetic variation within both the methylenetetrahydrofolate reductase (MTHFR) gene and the catechol-O-methyltransferase (COMT) gene has been associated with an increased risk of metabolic syndrome in schizophrenia patients treated with AAPs.
|
23341251 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that the MTHFR 677T allele might have effect on risk of schizophrenia, memory impairment and GMD changes in patients.
|
23318463 |
2013 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated a strong association between MTHFR A1298C and schizophrenia.
|
22813657 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population.
|
23076983 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.
|
22690662 |
2012 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
|
21185933 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients.
|
21980405 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Folate supplementation in schizophrenia: a possible role for MTHFR genotype.
|
21334854 |
2011 |
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, neither winter birth nor MTHFR genotype were significantly associated with increased schizophrenia risk.
|
21093223 |
2011 |