Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been speculated to be and extensively investigated as a risk factor for various vascular diseases, including intracerebral hemorrhage (ICH).
|
26757363 |
2016 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Prevalence of variants in methylenetetrahydrofolate reductase and the severity of pulmonary vascular disease.
|
25304246 |
2015 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with thrombophilia and vasculopathy that may result in oral ulceration.
|
23665953 |
2014 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) gene variants have been associated with vasculopathy that has been linked to diabetic neuropathy.
|
23901246 |
2013 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the methylenetetrahydrofolate reductase (MTHFR) enzyme, which is involved in homocysteine metabolism, have been investigated as potential vascular disease risk factors.
|
24310797 |
2013 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin.
|
22592843 |
2012 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
|
23285280 |
2012 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Blood samples from 70 patients with vascular disease and 70 healthy controls were analyzed for plasma homocysteine levels (chemiluminescent immunoassay) and for the presence of MTHFR C677T (polymerase chain reaction analysis).
|
22375042 |
2012 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To investigate the influence of MTHFR polymorphism on vascular disease risks in young Japanese females, we determined dietary intakes, serum folate and tHcy, and examined the influence of MTHFR 677C>T polymorphism in healthy junior and high school students (n=192, 12-18y).
|
22507617 |
2012 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) polymorphisms are associated with thrombophilia and vasculopathy that may result in cutaneous ulceration.
|
21482894 |
2011 |
Vascular Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia.
|
19646848 |
2009 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia.
|
19646848 |
2009 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases.
|
18855261 |
2008 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases.
|
17966140 |
2007 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
16564429 |
2006 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CBS 844ins68 lowers tHcy and negates the raising effect of MTHFR C(677)T in healthy subjects, but it is unclear if this is the case in subjects at high risk of vascular disease.
|
16259797 |
2005 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies.
|
15921520 |
2005 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene, one of the key enzymes catalyzing remethylation of homocysteine, may play a role in the development of not only vascular disease but also diabetic microangiopathies.
|
15126006 |
2004 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
15053827 |
2004 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We found raised median tHcy levels in all patient groups vs. controls (p < 0.05), with odds ratios (95% CI) for vascular disease among patients with HHcy (defined as > 15 micromol/l) of 3.9 (0.6 - 14.3), 4.8 (1.2 - 18.8) and 15.8 (2.8 - 87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels > 30 micromol/l had the MTHFR C677T homozygous substitution.
|
14698652 |
2003 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Standard methods were used to measure biochemical variables and to characterize vascular disease and MTHFR genotype.
|
12049616 |
2002 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene polymorphism are accepted risk factors for cardiovascular disease, their association with micro angiopathy or blood pressure in diabetic patients is still being debated.
|
12242465 |
2002 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects.
|
12356186 |
2002 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene is associated with decreased MTHFR activity and elevated plasma homocysteine levels with the result of an increased risk for vascular disease.
|
12052604 |
2002 |
Vascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A common mutation in methylenetetrahydrofolate reductase (MTHFR), 677C-->T, is associated with reduced enzyme activity, a thermolabile enzyme and mild hyperhomocysteinemia, a risk factor for vascular disease.
|
11395038 |
2001 |