Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus.
|
31321587 |
2019 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -493G/T polymorphism in the promoter region of MTP gene has been associated with HCV-related hepatic steatosis.
|
30790698 |
2019 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice.
|
27862118 |
2017 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the microsomal triglyceride transfer protein (-493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus.
|
28356060 |
2017 |
Fatty Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The T allele was associated with alterations in serum lipids and hepatic steatosis in all diseases and with reduced hepatic TM6SF2 and microsomal triglyceride transfer protein expression.
|
26822232 |
2016 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, mutations in apolipoprotein B and microsomal triglyceride transfer protein cause hepatic steatosis, in concordance with drugs that inhibit these targets.
|
26859812 |
2016 |
Fatty Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intestine-specific inhibitors of MTP decrease chylomicron biogenesis and improve insulin sensitivity in experimental animals and, while overcoming hepatic steatosis, may have significant gastrointestinal side effects that could limit their use in humans.
|
25552696 |
2015 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cases of MTTP gene mutation is characterized by abetalipoproteinemia and remarkable hepatic steatosis or cirrhosis.
|
26458397 |
2015 |
Fatty Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Yet, the development of MTP inhibitors to lower plasma lipid concentrations has been hindered by adverse effects on hepatic steatosis.
|
24201112 |
2013 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C.
|
19018985 |
2009 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
I/I genotype of MTTP gene frequency in the drinkers with fatty livers was 85.4%, which was significantly higher than that in the drinkers without fatty liver, which was 68.4% (P=0.013).
|
19262398 |
2009 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.
|
18482281 |
2008 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.
|
18482281 |
2008 |
Fatty Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease.
|
17303181 |
2007 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Circulating concentrations of adipokines (ie, tumor necrosis factor-alpha, adiponectin, resistin, leptin, and interleukin-6), markers of nitrosative stress (nitrotyrosine), dietary habits, and MTP -493G/T polymorphism were cross-sectionally related to the presence and severity of insulin resistance (homeostasis model assessment index for insulin resistance: >or=2), the metabolic syndrome, and fatty liver in 64 nonobese nondiabetic patients with NAFLD (33 insulin-sensitive and 31 insulin-resistant subjects) and 74 control subjects without liver disease who were matched for sex, BMI, homeostasis model assessment index for insulin resistance status, and the various features of the metabolic syndrome.
|
17823431 |
2007 |
Fatty Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis.
|
16697730 |
2006 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients.
|
16458034 |
2006 |
Fatty Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that reduced MTP activity is crucial to development of alcoholic fatty liver, while promotion of MTP activity by HGF might serve as a therapeutic measure against alcoholic liver steatosis.
|
11830326 |
2002 |
Fatty Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes.
|
10990076 |
2000 |