|
Abnormality of metabolism/homeostasis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acromegaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTRR-66AA genotype was significantly higher in the control group than the acromegaly group (p=0.004).
|
26154858 |
2015 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTHFR and MTRR genetic polymorphisms were not associated with AL.
|
22706675 |
2012 |
|
Acute lymphocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We conclude that abnormal MTRR mRNA expression and the methylation of the MTRR promoter can be used to classify the risk of ALL in children.
|
31002356 |
2019 |
|
Acute lymphocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL.
|
15797993 |
2005 |
|
Acute lymphocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The increase in risk of adult ALL with the RFC1 80AA associated with the MTRR 66GG variant was even more significant (OR = 8.92; 95% CI 1.97-40.42).
|
21657963 |
2011 |
|
Acute lymphocytic leukemia
|
0.060 |
Biomarker
|
disease |
BEFREE |
We analysed common genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS), methionine synthase (MS) and methionine synthase reductase (MTRR) in 68 children with ALL and 258 healthy controls to investigate their influence on the risk for ALL.
|
17454638 |
2007 |
|
Acute lymphocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in other folate related genes (MTRR, MTR [MS], TYMS [TS], SLC19A1 [RFC1], NNMT, and SHMT1) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited.
|
19775302 |
2010 |
|
Acute lymphocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
However, the results of stratified analyses revealed that MTRR A66G GG genotype was associated with decreased leukemia risk in the Caucasian population, in children and for acute lymphoblastic leukemia (ALL).
|
24261678 |
2014 |
|
Adenoma
|
0.300 |
Biomarker
|
group |
CTD_human |
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
|
17389618 |
2007 |
|
Adenoma of large intestine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This case-control study enrolled 105 new cases of CRC, 101 of colorectal adenoma (CRA), and 182 controls from hospitals in Bangkok, Thailand, to examine the association between folate status and methylenetetrahydrofolate reductase (MTHFR) 677C > T, methionine synthase (MTR) 2756A > G, and methionine synthase reductase (MTRR) 66A > G with the risk of CRC and CRA.
|
31740010 |
2019 |
|
Adenoma of large intestine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, the methionine synthase reductase (MTRR) Arg415Cys and MTRR Ser284Thr variant carriers, also in the vitamin B(12) pathway, have suggestive associations with advanced colorectal adenoma (defined as being larger than 1 cm, villous, tubular-villous or carcinoma in situ histology).
|
17389618 |
2007 |
|
Adenoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
|
17389618 |
2007 |
|
Adenoma, Microcystic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
|
17389618 |
2007 |
|
Adenoma, Monomorphic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
|
17389618 |
2007 |
|
Adenoma, Trabecular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
|
17389618 |
2007 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The increase in risk of adult ALL with the RFC1 80AA associated with the MTRR 66GG variant was even more significant (OR = 8.92; 95% CI 1.97-40.42).
|
21657963 |
2011 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Finally, those with the MS 2756AG/GG and MTRR 66AG/GG genotypes revealed a 2.2-fold ALL risk reduction (OR 0.45, 95% CI 0.10-0.85).
|
15159311 |
2004 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
Biomarker
|
disease |
BEFREE |
We analysed common genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR), thymidylate synthase (TS), methionine synthase (MS) and methionine synthase reductase (MTRR) in 68 children with ALL and 258 healthy controls to investigate their influence on the risk for ALL.
|
17454638 |
2007 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL.
|
15797993 |
2005 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We conclude that abnormal MTRR mRNA expression and the methylation of the MTRR promoter can be used to classify the risk of ALL in children.
|
31002356 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
However, the results of stratified analyses revealed that MTRR A66G GG genotype was associated with decreased leukemia risk in the Caucasian population, in children and for acute lymphoblastic leukemia (ALL).
|
24261678 |
2014 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ROS content and apoptosis rate increased in control fibroblasts and in a glioblastoma cell line by shRNA-mediated silencing of MTRR gene expression.
|
22887477 |
2013 |
|
Adult Liver Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, we detected potential heterogeneity across alcohol drinking status for ORs relating MTRR rs1801394 to esophageal (posterior homogeneity P = 0.005) and stomach cancer (posterior homogeneity P = 0.004), and ORs relating MTR rs1805087 to liver cancer (posterior homogeneity P = 0.021).
|
25337902 |
2014 |
|
Adult Meningioma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A significant association between risk of meningioma and homozygosity for MTRR 66G was also observed (OR, 1.41; 95% CI, 1.02-1.94).
|
18483342 |
2008 |