|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal globus pallidus morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To analyze MCM protein expression patterns in actinic keratosis (AK), Bowen disease (BD), and cutaneous squamous cell carcinoma (SCC), we performed immunohistochemical staining of MCM2, -5, and -7 on tissue microarray blocks from 91 AK, 50 BD, and 174 SCC samples.
|
27299186 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, MCM gene expression has not been well‑studied in lung adenocarcinoma (LUAD).
|
31545501 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our current study is to identify clinical significance of minichromosome maintenance (MCM) gene expression in Lung Adenocarcinoma (LUAD) using genome-wide RNA sequencing (RNA-seq) dataset and bioinformatics analysis tools.
|
31323040 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB).
|
28598542 |
2017 |
|
Alloimmunisation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cumulative alloimmunization incidence for MUT increased from 0.12% (95% confidence interval [CI], 0.03-0.21) to 0.63% (95% CI, 0.25-1.01), while for Mur it increased from 0.04% (95% CI, 0-0.09) to 0.42% (95% CI, 0.05-0.79) when a patient was transfused 2 RBC units as compared to 12.
|
29441590 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, FE65 interactions with BLM and MCM proteins may contribute to the neuronal cell cycle re-entry observed in brains affected by Alzheimer's disease.
|
23572515 |
2013 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MCM proteins are overexpressed in ATC and sustain the high proliferative capacity of ATC cells.
|
15899946 |
2005 |
|
Anemia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Survival analysis was used to identify potential prognostic values of MCM genes in PDAC overall survival (OS).
|
30233242 |
2018 |
|
Anorexia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Atrial Septal Defects
|
0.100 |
CausalMutation
|
group |
CLINVAR |
|
|
|
|
Blood spots
|
0.010 |
Biomarker
|
disease |
BEFREE |
DNA from the blood spots of the patient was analyzed for the MUT gene.
|
23729607 |
2013 |
|
Bowen's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To analyze MCM protein expression patterns in actinic keratosis (AK), Bowen disease (BD), and cutaneous squamous cell carcinoma (SCC), we performed immunohistochemical staining of MCM2, -5, and -7 on tissue microarray blocks from 91 AK, 50 BD, and 174 SCC samples.
|
27299186 |
2018 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
We have demonstrated that dysregulated expression of minichromosome maintenance (MCM) proteins 2-7 is characteristic of early epithelial carcinogenesis, and that these key DNA replication initiation factors can be used as diagnostic markers for cervical and genito-urinary tract cancer.
|
15266314 |
2004 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The upregulation of MCM genes expressions in cervical carcinogenesis reaffirms MCM as a proliferative marker in DNA replication pathway, whereby proliferation of dysplastic and cancer cells become increasingly dysregulated and uncontrolled.
|
31653153 |
2019 |
|
Carcinoma of ampulla of Vater
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer.
|
9808525 |
1998 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, MCMs and PHGDH can be poor prognostic factors for lung cancer.
|
29888431 |
2018 |
|
Carcinoma, Transitional Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Through data mining of a published transcriptome of UBUC (GSE31684), we identified Minichromosome Maintenance Complex Component 2 (MCM2) and MCM10 as the two most significantly upregulated genes in UC progression among the MCM gene family, the key factors for the initiation of DNA replication.
|
27780919 |
2016 |
|
Cardiomyopathies
|
0.110 |
Biomarker
|
group |
HPO |
|
|
|
|
Cardiomyopathies
|
0.110 |
Biomarker
|
group |
BEFREE |
We measured the mRNA levels, the protein levels and the number of high affinity [3H]ryanodine binding sites in the left ventricle of non-failing (n = 9) and failing human hearts [idiopathic dilated (IDCM n = 16), ischemic (ICM n = 7) or mixed (MCM n = 8) cardiomyopathies].
|
9160875 |
1997 |
|
Cardiomyopathy, Familial Idiopathic
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.
|
27604308 |
2016 |
|
Cataract, total congenital with posterior sutural opacities in Heterozygotes
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study suggests that disruption of the p53-pathway by MUT-TP53in hotspot/direct DNA contact codons is predictive of outcome in CCT-treated PCNSL patients, and concomitant MUT-TP53 and MIR34A methylation are associated with poor PFS.
|
27101868 |
2016 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Currently, a consistent reduction of the MUT protein expression was obtained in the neuroblastoma cell line (SH-SY5Y) by using small-interfering RNA (siRNA) directed against an MUT transcript (MUT siRNA).
|
30428564 |
2018 |