|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Eight PVs in ATM, BRCA2 (x2), PALB2, RAD51D, BRIP1, and MUTYH (x2) were identified in 7 of 44 individuals with breast cancer (15.9%, 95% CI: 7-30%), whereas none were identified in healthy controls (p = .01).
|
31575519 |
2020 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To the best of our knowledge, this report is the first to describe the highly pathogenic variant in the BRCA2 gene (rs483353122) and the likely damaging germline variant in the MUTYH gene (rs35352891) in Russian Mongoloid BC patients with young-onset and/or bilateral and/or familial BC.
|
31273614 |
2019 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study did not find a significant increase in breast cancer risk associated with monoallelic MUTYH mutations.
|
30582135 |
2019 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The presence of the 326Cys/Cys genotype and 326Cys allele of OGG1 gene and the 324His/His of MUTYH gene are associated with increased risk of BC development.
|
27870262 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The HRs (95% CI) for monoallelic MUTYH mutation carriers were: gastric cancer 9.3 (6.7-13); hepatobiliary cancer 4.5 (2.7-7.5); endometrial cancer 2.1 (1.1-3.9) and breast cancer 1.4 (1.0-2.0).
|
27194394 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An increase in breast cancer risk was observed for women with the MUTYH_rs3219489 variant allele (odds ratio (OR)=2.23, 95% confidence interval (CI)=1.10-4.52) and for women with the MSH2_rs2303428 variant allele (OR=1.73, 95% CI=1.00-2.99).
|
27630279 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluate an association with breast cancer (BC), following up our previous finding of an elevated BC frequency among Dutch bi-allelic MUTYH mutation carriers.
|
22297469 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriers of variants in MutYH, although not very common, may have an increased risk of breast cancer in Jews of North African origin.
|
21952991 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Considering the relationship between carcinogenesis and oxidative stress, an investigation was held on whether the common variant of the MUTYH gene increases the risk for gastric and breast cancers.
|
22126480 |
2011 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Yet, the involvement of MUTYH mutations in families with both breast cancer and colorectal cancer is unclear.
|
20191381 |
2010 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the MYH gene do not substantially contribute to the risk of breast cancer.
|
18454351 |
2009 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether genetic variation in six BER pathway genes (XRCC1, ADPRT, APEX1, OGG1, LIG3, and MUTYH) is associated with breast cancer risk in two large population-based case-control studies in the United States (3,368 cases and 2,880 controls) and Poland (1,995 cases and 2,296 controls).
|
16492928 |
2006 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|