MX1, MX dynamin like GTPase 1, 4599

N. diseases: 71; N. variants: 7
Disease: Influenza ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Since MxA is archetypic of Mx1 proteins in general, we reasoned that the L4 loop also functions as a recognition platform for influenza viruses in the Mx1 proteins of other species that had been exposed to the virus for ever. 30939061 2019
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Chicken Mx1 gene, as a positive antiviral gene, has been reported to provide resistance to several viruses especially avian influenza virus. 30456017 2018
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Mouse MX1 interacts with the influenza ribonucleoprotein complexes (vRNPs) and can prevent the interaction between polymerase basic 2 (PB2) and the nucleoprotein (NP) of influenza A viruses. 28011636 2017
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Here, we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gene from the A2G strain are not fully protected against lethal influenza virus infections. 26202236 2015
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE Finally, human MX1 (also known as MXA), a closely related protein that has long been recognized as a broadly acting inhibitor of RNA and DNA viruses, including the orthomyxovirus influenza A virus, does not affect HIV-1, whereas MX2 is ineffective against influenza virus. 24048477 2013
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease CTD_human A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 23326326 2013
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. 22190720 2012
CUI: C0021400
Disease: Influenza
Influenza 		0.400 AlteredExpression disease BEFREE These results demonstrate for the first time that uncontrolled influenza A virus replication actively suppresses MxA gene expression and emphasize the critical role of innate immunity in controlling influenza virus replication in vivo. 18250448 2008
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. 17700072 2007
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease LHGDN Stimulus-dependent and domain-dependent cell death acceleration by an IFN-inducible protein, human MxA. 16704297 2006
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease LHGDN Promoted cell death of cells expressing human MxA by influenza virus infection. 11911186 2002
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE MxA protein confers resistance to influenza viruses, and we have previously shown that MxA protein is strongly expressed in lesional anagen hair bulbs from patients with AA but not in normal follicles. 10942113 2000
CUI: C0021400
Disease: Influenza
Influenza 		0.400 GeneticVariation disease BEFREE Promoter structure of the MxA gene that confers resistance to influenza virus. 9428735 1997
CUI: C0021400
Disease: Influenza
Influenza 		0.400 Biomarker disease BEFREE In humans the MxA protein has antiviral activities against influenza viruses. 7551417 1995