MX1, MX dynamin like GTPase 1, 4599

N. diseases: 71; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 GeneticVariation disease BEFREE As SNPs on MxA promoter region might participate in MS patients' response to IFNβ, prior patients genotyping may increase the rate of responsiveness and help in individualized selection of treatment options. 28386647 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 AlteredExpression disease BEFREE Myxovirus A (MxA), a protein encoded by the MX1 gene with antiviral activity, has proven to be a sensitive measure of IFNβ bioactivity in multiple sclerosis (MS). 21886806 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 Biomarker disease BEFREE To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. 17188754 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 AlteredExpression disease BEFREE No significant association was found between the MXA genotype at these two SNPs and clinical, MRI and MXA gene expression in MS patients treated with IFN-beta therapy. 17126411 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 Biomarker disease LHGDN Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1. 16459719 2006
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.060 Biomarker disease BEFREE SNPs on MxA promoter region may play an important role in the pathophysiology of MS and provide a novel strategy for the therapeutic resolutions of MS. 16843495 2006