MX1, MX dynamin like GTPase 1, 4599

N. diseases: 71; N. variants: 7
Disease: Virus Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE These data support the consideration of Mx1-9R as a novel therapeutic agent against mucosal influenza virus infection. 30696001 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE MxA protein production in peripheral blood cells has been shown to be a clinically sensitive and specific marker for viral infection. 30593466 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 GeneticVariation group BEFREE Furthermore, in genetic mapping studies, Mx1 was identified as the major locus of resistance to influenza virus infections. 26202236 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN)-triggered dynamin-like multi-domain GTPase involved in innate immune responses against viral infections. 26411585 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE Expression of the MxA gene has been found to be a reliable and sensitive marker for the induction of endogenous type I interferons (IFNs) during viral infections. 20002306 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. 10400797 1999
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE In mice the Mx1 protein has been shown to be necessary and sufficient to protect against influenza virus infection because the resistance does not require a functioning immune system. 7551417 1995