MXI1, MAX interactor 1, dimerization protein, 4601

N. diseases: 128; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.050 AlteredExpression group BEFREE High-level MAD2 expression was observed in 26.3% (94 of 358 cases), and correlated with male sex (P=0.0002), tumor progression (pT status) (P=0.0009), visceral or parietal pleural invasion (P=0.0151), non-adenocarcinoma, histological classification (P<0.0001), and smoking history (P=0.0022), but not with patient age or lymph node metastasis (pN status). 21376419 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.050 Biomarker group BEFREE We wanted to investigate whether Aurora A, Aurora B, BUB1B and Mad2 were associated with the development of aneuploidy in colorectal adenocarcinomas as suggested by several in vitro studies, and if their protein levels were related to alterations at the corresponding chromosomal loci. 18699967 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.050 AlteredExpression group BEFREE Gene expression levels of the MAD2 and BUB1 mitotic spindle checkpoint genes were assessed in 37 Barrett's patients (with histology ranging from metaplasia to adenocarcinoma) by real-time RT-PCR. 15013707 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.050 AlteredExpression group BEFREE Mad2 was significantly overexpressed in colorectal cancer compared with corresponding normal mucosa (P<0.01, chi(2) = 7.5), and it was related to the differentiation of adenocarcinoma, lymph node metastasis and survival period after excision (P<0.05, chi(2) = 7.72, chi(2) = 4.302, chi(2) = 6.234). 15457580 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.050 GeneticVariation group BEFREE We examined 40 primary human pancreatic adenocarcinomas for MXI1 mutations. 8603382 1996