|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although with the majority of the specimens there was no obvious correlation between the morphologic cell type of lymphoma/leukemia and the c-onc RNA levels, interestingly two of the three samples diagnosed as chronic lymphocytic leukemia, B-cell type, showed considerably increased transcription of the c-myc gene relative to the other B-cell neoplasms.
|
6603429 |
1983 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
By using probes specific for the c-mos and c-myc genes, we have analysed the genomic DNA from peripheral blood and bone marrow samples from 15 patients with various malignant myeloid diseases, including leukemia and myelodysplasia, and from one patient with non-Hodgkin's lymphoma, all of whom have trisomy for chromosome No.8.
|
4079453 |
1985 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1.
|
3284178 |
1988 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this leukemia, Northern blot and nuclease analyses SI showed that MYC was strongly expressed with initiation of the transcription at both the 5' and 3' promoters as observed in Burkitt's lymphomas; no coding change was observed in MYC putative regulatory sequences.
|
2069907 |
1991 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the BCL-3 rearranged cases showed MYC gene rearrangement, as reported for the original leukemia that led to the discovery of BCL-3.
|
8400234 |
1993 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
All N/L-myc positive leukemias and leukemia cell lines coexpress the c-myc gene, thus exemplifying a lack of negative cross-regulation between the different myc genes in leukemia cells.
|
8260894 |
1993 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have used a monoclonal antibody for the c-myc protein to investigate the level of expression in 11 patients with T-PLL and two with Sezary cell leukemia and compared it with levels seen in normal lymphocytes.
|
7564512 |
1995 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the proto-oncogene c-myc was in the germline configuration in the initial leukemia but in the rearranged configuration after transformation.
|
9402334 |
1997 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This appears to be the largest MYC-containing amplicon in human leukemia.
|
10686942 |
1999 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of additional cases of leukemia with translocations involving the MYC locus on 8q24 will be required to determine the frequency of association with the cryptic t(12;21)(p13;22), and the prognostic significance of the simultaneous occurrence of the translocations.
|
11106815 |
2000 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no mutations in the c-myc gene in any of the leukemia cell lines that could account for increased c-Myc stability.
|
16855632 |
2006 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
After Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc.
|
18593890 |
2008 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch.
|
19351371 |
2009 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dual-hit lymphoma/leukemia is a rare but distinct mature B-cell neoplasm with an extremely poor prognosis characterized by frequent extranodal involvement and central nervous system progression with either of the translocation partners of MYC.
|
19535347 |
2009 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that KIT mutations lead to MYC-dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia.
|
20385359 |
2010 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concomitant and successive amplifications of MYC in APL-like leukemia.
|
20113841 |
2010 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of BET bromodomain-promoter interactions and subsequent reduction of MYC transcript and protein levels resulted in G(1) arrest and extensive apoptosis in a variety of leukemia and lymphoma cell lines.
|
21949397 |
2011 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A pediatric B lineage leukemia with coincident MYC and MLL translocations.
|
20829716 |
2011 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that all six members of the anti-apoptotic BCL2 gene family can cooperate with (myelocytomatosis oncogene) MYC in a mouse model of leukemia, but three of them are significantly less potent contributors to leukemogenicity than the other three.
|
22233804 |
2012 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that AFF4/SEC could be a potential therapeutic target for the treatment of leukemia or other cancers associated with MYC overexpression.
|
22547686 |
2012 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
|
23079661 |
2012 |
|
Childhood Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently inhibitors of bromodomain and extra-terminal (BET) family proteins have shown antitumor effects through the suppression of MYC in leukemia and lymphoma.
|
25299775 |
2014 |
|
Childhood Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown that the c-Myc promoter quadruplex-forming sequence Pu-27 selectively kills transformed cells (Sedoris, K. C., Thomas, S. D., Clarkson, C. R., Muench, D., Islam, A., Singh, R., and Miller, D. M. (2012) Genomic c-Myc quadruplex DNA selectively kills leukemia.Mol.Cancer Ther.11, 66-76).
|
24464582 |
2014 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.
|
26046133 |
2015 |
|
Childhood Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of CXCR4 targeted key T-ALL regulators, including the MYC pathway, and decreased leukemia initiating cell activity in vivo.
|
26058075 |
2015 |