|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-myc gene in human hepatoma.
|
2415125 |
1985 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the hypomethylation in the third exon of the c-myc gene is probably important for the development of HCC.
|
3040653 |
1987 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that continued expression of HBsAg or the presence of hepatitis B virus DNA/RNA in a given human hepatocellular carcinoma cell id not necessary for enhanced expression of ras or c-myc proteins.(ABSTRACT TRUNCATED AT 250 WORDS)
|
2843452 |
1988 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the high transcript level observed in the non-cancerous tissue from the excised liver relates to liver resection itself, and that the c-myc gene expression is enhanced in the HCC.
|
2548493 |
1989 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expression of the c-myc gene has previously been shown to be elevated and deregulated in the human hepatoma cell line Hep G2 (B. E. Huber and S. S. Thorgeirsson, Cancer Res., 47: 3414-3420, 1987).
|
2154325 |
1990 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies of naturally occurring animal models, such as woodchucks and squirrels infected with hepatitis B-like viruses (hepadnaviruses) have revealed different oncogenic strategies and outlined the predominant role of myc genes in rodent hepatomas.
|
1335794 |
1992 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance.
|
7511953 |
1993 |
|
Liver carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Amplification and overexpression of the c-myc gene has been a common finding in HCCs of ground squirrels, and is rare in woodchuck or human HCCs.
|
8198385 |
1994 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of c-myc gene without gene amplification in human hepatocellular carcinoma.
|
9275322 |
1996 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes.
|
9029167 |
1997 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The biologic significance of c-myc gene amplification in human hepatocellular carcinoma, however, is unconfirmed.
|
10461064 |
1999 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the proto-oncogene c-myc is a common phenomenon in hepatocellular carcinoma (HCC).
|
11148566 |
2001 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis.
|
12029619 |
2002 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma(HCC).
|
12378623 |
2002 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
On analyzing the relationship between alterations of beta-catenin or Tcf-4 and C-myc or Cyclin D1 expression, we found that the mutations of beta-catenin as well as over expression of beta-catenin or Tcf-4 gene were independently correlated with C-myc gene over expression in HCCs.
|
14687479 |
2003 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
On analyzing the relationship between alterations of beta-catenin or Tcf-4 and C-myc or Cyclin D1 expression, we found that mutations of beta-catenin, as well as overexpression of beta-catenin or the Tcf-4 gene were independently correlated with C-myc gene overexpression in HCC.
|
12603528 |
2003 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Expression of c-myc mRNA in hepatocellular carcinomas, noncancerous livers, and normal livers.
|
15459488 |
2004 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Application of comparative functional genomics to identify best-fit mouse models to study human cancer.
|
15565109 |
2004 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
High-throughput analysis of c-myc gene amplification and expression using dual-color fluorescence in situ hybridization and immunohistochemistry was performed on tissue microarrays consisting of 458 liver samples comprising HCCs, nontumorous livers and normal livers.
|
15668888 |
2004 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
LHGDN |
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma.
|
14991929 |
2004 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
With the aim to develop therapeutic strategies for HCC, we constructed several mono- and bicistronic antisense recombinants against HBx and c-myc genes to regulate their expression as well as transactivation function in a human hepatoma cell line.
|
16616001 |
2006 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Consistent with the recently reported association between c-MYC overexpression and induction of telomerase activity, we find here that GA treatment of a human hepatoma cell line SMMC-7721 significantly reduced the expression of c-MYC in a time- and concentration-dependent manner accompanied with the down-regulation of the hTERT transcription and the ultimate reduction in telomerase activity.
|
16257012 |
2006 |
|
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Both MYC and transforming growth factor alpha (TGFalpha) are commonly over-expressed in hepatocellular carcinomas, and transgenic mice expressing these genes rapidly develop tumors via the suppression of MYC-induced apoptosis by the growth factor.
|
17698969 |
2007 |
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
LHGDN |
Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver.
|
17587243 |
2007 |