|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results, together with those obtained in human neuroblastoma, suggest that the distal part of the short arm of chromosome 1 harbors an unidentified tumor suppressor gene(s), whose inactivation may be involved in MYC family gene amplification (an example of genetic instability) in tumors of various cellular origins.
|
7913873 |
1994 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the proto-oncogene, c-myc, in human neuroblastoma cells by reversible inhibition of cell growth.
|
1776829 |
1992 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data highlight a novel route for cell death induction by PARP inhibitors and support their introduction, together with CHK1 inhibitors, in therapeutic approaches for neuroblastomas with high MYC(N) activity.
|
28394338 |
2017 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
N6,2'-O-dibutyryladenosine 3':5'cyclic monophosphate (Bt2cAMP) inhibited neuroblastoma cell growth by inhibiting c-MYC and HDAC8 expression and activating caspase 3.
|
30237861 |
2018 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Exposures mimicking conditions of CO (2) pneumoperitoneum lead to significant overexpression of C-MYC and HMGB-1 in neuroblastoma cells with decreased apoptosis.
|
19387923 |
2009 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found that MELK is a direct transcription target of MYCN and MYC in NB, and MYCN increases MELK expression via direct promoter binding.
|
29416794 |
2018 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated.
|
12545167 |
2003 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
MYCN and MYC play a crucial role in determining the malignancy of unfavorable neuroblastomas, whereas high-level expression of the favorable neuroblastoma genes is associated with a good disease outcome and confers growth suppression of neuroblastoma cells.
|
24173829 |
2014 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We review the latest approaches envisioned for blockade of ALK activity in neuroblastoma, present a classification of potential approaches for therapeutic targeting of MYCN, and discuss how recent developments in targeting of MYC proteins seem to make therapeutic inhibition of MYCN a reality in the clinic.
|
23965898 |
2013 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma.
|
29207623 |
2017 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of class I histocompatibility antigens in neuroectodermal tumors is independent of the expression of a transfected neuroblastoma myc gene.
|
2687378 |
1989 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further, despite compelling evidence for MYC and RAS cooperation in vitro and in vivo to promote tumourigenesis, activation of RAS signal transduction does not constitute a preferred secondary pathway in neuroblastomas with MYCN deregulation in either human tumors or murine models.
|
16822308 |
2006 |
|
Neuroblastoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We showed that Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas.
|
22068108 |
2011 |
|
Neuroblastoma
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|