Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We demonstrate that IBD-associated intestinal adenocarcinomas have a high frequency of c-MYC amplification that is associated with mucinous and signet ring cell differentiation.
|
29788391 |
2018 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Whereas the frequency of MYC amplification was similar to adenocarcinoma (10.5% versus 4%, P = .2), the frequency of PTGER4 amplification was higher than adenocarcinoma (10.5% versus 0.3%, P = .01).
|
28899736 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Considering that α1 subunit/<i>ITGA1</i> expression is correlated with MYC in more than 70% of colon adenocarcinomas, we postulated that the integrin α1β1 has a pro-tumoral contribution to CRC.
|
28933766 |
2017 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
By contrast, mice with both alterations (Hoxb13-MYC∣Hoxb13-Cre∣Pten(Fl/Fl), hereafter, BMPC mice) developed lethal adenocarcinoma with distant metastases and widespread genome CNAs that were independent of forced disruption of Tp53 and telomere shortening.
|
26554830 |
2016 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling.
|
26432044 |
2015 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
c-MYC gain (but not chromosome 8 gain or c-MYC amplification) was an independent poor-prognostic factor for DFS and OS in lung adenocarcinomas, both in full cohort and stage I cancer, and possibly for DFS in EGFR-mutant adenocarcinomas.
|
24809777 |
2014 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes.
|
24858378 |
2014 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transgenic MYC expression drives invasive adenocarcinomas in the murine prostate.
|
22585994 |
2012 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the context of compound Pten/p53 heterozygosity, c-MYC-initiated cells progress to prostatic intraepithelial neoplasia (mPIN) and adenocarcinoma lesions with marked heterogeneity within the same prostate glands.
|
21685943 |
2012 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, in a series of gastric adenocarcinomas we studied the association of p27(KIP1) expression with H. pylori genotype (vacA, cagA, cagE and virB11) and the involvement of C-MYC in this process.
|
20059402 |
2010 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of the present study is to determine the presence and molecular integrity of high-risk HPV types in colorectal adenocarcinomas and to assess whether viral DNA is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer.
|
20232185 |
2010 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus.
|
18559552 |
2008 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
MYC and gastric adenocarcinoma carcinogenesis.
|
18932273 |
2008 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil.
|
18262050 |
2008 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
Amplification of c-myc and cyclin D1 genes in primary and metastatic carcinomas of the liver.
|
17587243 |
2007 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study was conducted to assess the frequencies of protein overexpression and gene amplification of Myc and to identify the mechanisms of Myc gene amplification, especially with regards to its possible coamplification with ERBB2 or EGFR in gastric adenocarcinomas.
|
17431415 |
2007 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
c-myc amplification is frequent in esophageal adenocarcinoma and correlated with the upregulation of VEGF-A expression.
|
16984727 |
2006 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil.
|
16886612 |
2006 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas.
|
16309200 |
2006 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
K-RAS point mutation, as well as amplification of C-MYC and C-ERBB2 were searched in 84 primary colon adenocarcinomas resected with curative intent.
|
15493579 |
2004 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased copy number of the ERBB2 (1 of 22), GATA4 (1 of 22), KRAS (2 of 22), C-MYC (1 of 22), CCNE1 (2 of 22), and CCND1 (2 of 22) genes was also observed in one or more Barrett's adenocarcinomas with HGD.
|
14581353 |
2003 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interference of mouse polyomavirus with the c-myc gene and its product in mouse mammary adenocarcinomas.
|
12851682 |
2003 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the present study, amplification of the proto-oncogene c-myc was determined by means of differential polymerase chain reaction analysis of metaplastic specialized epithelium, low-grade dysplasia, high-grade dysplasia, and invasive adenocarcinoma obtained by microscopic dissection of 43 esophagectomy specimens.
|
11392879 |
2001 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that deregulated c-MYC expression in this inducible system results in the formation of invasive mammary adenocarcinomas, many of which fully regress following c-MYC deinduction.
|
11175856 |
2001 |